Literature DB >> 12608858

Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum.

Lark J Perez1, D John Faulkner.   

Abstract

The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.

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Year:  2003        PMID： 12608858     DOI： 10.1021/np0204601

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  16 in total

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