Literature DB >> 12608850

Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities.

Chihiro Ito1, Masataka Itoigawa, Yoshiaki Miyamoto, Saori Onoda, K Sundar Rao, Teruo Mukainaka, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa.   

Abstract

In a further study on the chemical constituents of Garcinia assigu, two new benzophenones corresponding to the 13-O-methyl ethers (1 and 2) of the known isogarcinol and garcinol, respectively, were isolated and characterized, along with known benzophenones (3-6). Inhibitory effects of the benzophenones isolated from this plant on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and their radical-scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were demonstrated. The cyclized polyprenylbenzophenones (1-5) showed comparable or stronger potential cancer chemopreventive activity when compared to glycyrrhetic acid, a known anti-tumor promoter.

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Year:  2003        PMID： 12608850     DOI： 10.1021/np020372g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  21 in total

1.  Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.

Authors:  Shugeng Cao; Peggy J Brodie; James S Miller; Fidy Ratovoson; Chris Birkinshaw; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-03-10       Impact factor: 4.050

2.  Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers.

Authors:  Brienne Sprague; Qian Shi; Marlene T Kim; Liying Zhang; Alexander Sedykh; Eiichiro Ichiishi; Harukuni Tokuda; Kuo-Hsiung Lee; Hao Zhu
Journal:  J Comput Aided Mol Des       Date:  2014-05-20       Impact factor: 3.686

3.  Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations.

Authors:  Jonathan H Boyce; Vincent Eschenbrenner-Lux; John A Porco
Journal:  J Am Chem Soc       Date:  2016-10-27       Impact factor: 15.419

4.  Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents.

Authors:  Jin Tatsuzaki; Kyoko Nakagawa-Goto; Harukuni Tokuda; Kuo-Hsiung Lee
Journal:  J Asian Nat Prod Res       Date:  2010-03       Impact factor: 1.569

5.  The total synthesis of hyperpapuanone, hyperibone L, epi-clusianone and oblongifolin A.

Authors:  Nicole Biber; Katrin Möws; Bernd Plietker
Journal:  Nat Chem       Date:  2011-10-16       Impact factor: 24.427

6.  Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity.

Authors:  Michelle R Garnsey; James A Matous; Jesse J Kwiek; Don M Coltart
Journal:  Bioorg Med Chem Lett       Date:  2011-02-23       Impact factor: 2.823

7.  Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K.

Authors:  Ji Qi; Aaron B Beeler; Qiang Zhang; John A Porco
Journal:  J Am Chem Soc       Date:  2010-10-06       Impact factor: 15.419

8.  Antiangiogenic effect of 2-benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1alpha and down regulation of VEGF of in-vivo.

Authors:  B T Prabhakar; Shaukath Ara Khanum; S Shashikanth; Bharathi P Salimath
Journal:  Invest New Drugs       Date:  2006-11       Impact factor: 3.850

9.  Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization.

Authors:  Jonathan H Boyce; John A Porco
Journal:  Angew Chem Int Ed Engl       Date:  2014-06-10       Impact factor: 15.336

Review 10.  Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Authors:  Subhash Padhye; Aamir Ahmad; Nikhil Oswal; Fazlul H Sarkar
Journal:  J Hematol Oncol       Date:  2009-09-02       Impact factor: 17.388
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