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Literature DB >> 1260766

Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class.

R J Owellen, C A Hartke, R M Dickerson, F O Hains.

Abstract

A series of Vinca alkaloids were found to block polymerization of crude tubulin extracts of porcine brain in a dose-dependent manner. This appears to be a specific effect occurring at low concentrations of drug. The concentration of vinblastine that prevents polymerization by 50% was 4.3 x 10(-7) mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with levels achieved in vivo following routine pharmacological doses in humans.

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Year: 1976 PMID： 1260766

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

50 in total

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5. Effect of the antitumor drug vinblastine on nuclear betaII-tubulin in cultured rat kidney mesangial cells.

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Journal: Invest New Drugs Date: 2003-02 Impact factor: 3.850

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Journal: J Nat Prod Date: 2013-09-09 Impact factor: 4.050

Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class.

1. Pharmacokinetic characteristics of vincristine sulfate liposomes in patients with advanced solid tumors.

2. Total synthesis of (-)- and ent-(+)-vindoline.

3. Which therapy works better in choroid plexus carcinomas?

4. Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine.

5. Effect of the antitumor drug vinblastine on nuclear betaII-tubulin in cultured rat kidney mesangial cells.

6. Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

Review 7. Natural Products in the "Marketplace": Interfacing Synthesis and Biology.

8. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues.

9. Antitubulin activity of vinblastine and vincristine. Clinical implications of the radial segmentation test.

10. Effective second line chemotherapy of advanced breast cancer with navelbine and mitomycin C.