Literature DB >> 7250174

Antitubulin activity of vinblastine and vincristine. Clinical implications of the radial segmentation test.

G Simmingsköld, B Norberg, A Norberg, U B Söderström.   

Abstract

The antitubulin activity of vinblastine and vincristine was compared by means of the radial segmentation test. Vinblastine was found to have antitubulin activity at least 6 times higher than that of vincristine. It is concluded that, if the differential indications for vinblastine or vincristine are balanced, it may be decisive for clinical treatment that more antitubulin activity can be administered as vinblastine than as vincristine.

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Year:  1981        PMID： 7250174     DOI： 10.1007/bf00548584

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  13 in total

Review 1.  Microtubules as drug receptors: pharmacological properties of microtubule protein.

Authors:  L Wilson
Journal:  Ann N Y Acad Sci       Date:  1975-06-30       Impact factor: 5.691

2.  Pharmacokinetics of vindesine and vincristine in humans.

Authors:  R J Owellen; M A Root; F O Hains
Journal:  Cancer Res       Date:  1977-08       Impact factor: 12.701

3.  The oxalate-induced radial segmentation of the nuclei in peripheral blood lymphocytes of different size.

Authors:  U B Söderström; B Norberg; L Brandt
Journal:  Scand J Haematol       Date:  1976-07

4.  The difference between random movement and chemotaxis. Effects of antitubulins on neutrophil granulocyte locomotion.

Authors:  U Bandmann; L Rydgren; B Norberg
Journal:  Exp Cell Res       Date:  1974-09       Impact factor: 3.905

5.  Analysis of polymorphonuclear leukocyte (PMN) migration by the leading-front technique. Random locomotion and chemotaxis.

Authors:  U B Söderström; G Simmingsköld; B Norberg; O Bäck; L Rydgren
Journal:  Exp Cell Res       Date:  1979-07       Impact factor: 3.905

6.  Polymorphonuclear leucocyte chemotaxis in Boyden chambers. Effect of low concentrations of vinblastine.

Authors:  U Bandmann; B Norberg; L Rydgren
Journal:  Scand J Haematol       Date:  1974

7.  The oxalate-induced radial segmentation of the nuclei of lymphocytes and monocytes from peripheral blood. A possible screening test for metaphase-blocking agents.

Authors:  B Norberg; R Uddman
Journal:  Blut       Date:  1973-04

8.  Interaction of drugs with microtubule proteins.

Authors:  L Wilson; J R Bamburg; S B Mizel; L M Grisham; K M Creswell
Journal:  Fed Proc       Date:  1974-02

9.  Contractile processes in human lymphocytes and monocytes from peripheral blood. The oxalate-induced radial segmentation of the nuclei and the ATP-induced migration of glycerinated cell models.

Authors:  B Norberg
Journal:  Scand J Haematol Suppl       Date:  1971

10.  Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro.

Authors:  R H Himes; R N Kersey; I Heller-Bettinger; F E Samson
Journal:  Cancer Res       Date:  1976-10       Impact factor: 12.701
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