Literature DB >> 12607179

Cognitive impairment in systemic lupus erythematosus and neuropsychiatric systemic lupus erythematosus: a population-based neuropsychological study.

Jukka Loukkola1, Matti Laine, Hanna Ainiala, Jukka Peltola, Riina Metsänoja, Anssi Auvinen, Aki Hietaharju.   

Abstract

We present a cross-sectional, population-based neuropsychological study of systemic lupus erythematosus (SLE) patients identified within Tampere University Hospital district, Finland with 440,000 inhabitants. Patients with definite SLE in the age range of 16-65 years (n = 46) and matched controls (n = 46) underwent neurological examination and comprehensive neuropsychological testing. On the basis of medical examination, the SLE patients were divided into neuropsychiatric (NP+; n = 15) and nonneuropsychiatric (NP-; n = 31) cases. The neuropsychological test results revealed more prevalent cognitive impairment in the NP+ patients, indicating that this subgroup mostly accounts for neuropsychological changes in SLE. Most characteristic changes in NP+ were observed in domains of memory, psychomotor speed, and complex attention. This suggests nonspecific CNS involvement, which is in line with neurological manifestations of the disease.

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Year:  2003        PMID： 12607179     DOI： 10.1076/jcen.25.1.145.13621

Source DB:  PubMed          Journal:  J Clin Exp Neuropsychol        ISSN： 1380-3395            Impact factor:   2.475


  9 in total

1.  Comparison of systemic lupus erythematosus patients and healthy individuals in terms of autobiographical memory, mood, and cognitive emotion regulation.

Authors:  Mahshid Taherzadeh; Mahgol Tavakoli
Journal:  Cogn Process       Date:  2020-06-03

2.  White-matter integrity in patients with systemic lupus erythematosus and memory deficits.

Authors:  Diogo G Corrêa; Nicolle Zimmermann; Rafael S Borges; Denis B Pereira; Thomas M Doring; Gustavo Tukamoto; Rochele P Fonseca; Emerson L Gasparetto
Journal:  Neuroradiol J       Date:  2018-08-09

3.  Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE.

Authors:  G Y Liu; T O Utset; J T Bernard
Journal:  Lupus       Date:  2015-04-16       Impact factor: 2.911

4.  Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus.

Authors:  E S Husebye; Z M Sthoeger; M Dayan; H Zinger; D Elbirt; M Levite; E Mozes
Journal:  Ann Rheum Dis       Date:  2005-02-11       Impact factor: 19.103

5.  Episodic memory impairment in systemic lupus erythematosus: involvement of thalamic structures.

Authors:  Nicolle Zimmermann; Diogo Goulart Corrêa; Tania Maria Netto; Tadeu Kubo; Denis Batista Pereira; Rochele Paz Fonseca; Emerson Leandro Gasparetto
Journal:  Clin Rheumatol       Date:  2015-01-10       Impact factor: 2.980

Review 6.  Cognitive and emotional abnormalities in systemic lupus erythematosus: evidence for amygdala dysfunction.

Authors:  Philip Watson; Justin Storbeck; Paul Mattis; Meggan Mackay
Journal:  Neuropsychol Rev       Date:  2012-08-11       Impact factor: 7.444

Review 7.  Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis.

Authors:  R H B Benedict; J L Shucard; R Zivadinov; D W Shucard
Journal:  Neuropsychol Rev       Date:  2008-06-03       Impact factor: 7.444

Review 8.  Systemic lupus erythematosus involving the nervous system: presentation, pathogenesis, and management.

Authors:  Julia J Rhiannon
Journal:  Clin Rev Allergy Immunol       Date:  2008-06       Impact factor: 8.667

9.  Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus.

Authors:  Yan Yang; Chao Yuan; Shu-Qun Shen; Xue-Er Wang; Qing-Hua Mei; Wen-Qing Jiang; Qin Huang
Journal:  Mediators Inflamm       Date:  2017-01-05       Impact factor: 4.711
  9 in total

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