Literature DB >> 12604563

In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes.

Yong-Taek Jun1, Hee-Jung Kim, Min-Jin Song, Ji-Hyang Lim, Dong-Gun Lee, Kyung-Ja Han, Su-Mi Choi, Jin-Hong Yoo, Wan-Shik Shin, Jung-Hyun Choi.   

Abstract

Ciprofloxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency.

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Year:  2003        PMID： 12604563      PMCID： PMC149341          DOI： 10.1128/AAC.47.3.1161-1164.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

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Journal:  Biochem Biophys Res Commun       Date:  1999-07-05       Impact factor: 3.575

6.  Limited effects of temafloxacin compared with ciprofloxacin on T-lymphocyte function.

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Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

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Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

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10.  Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood.

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Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
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2.  Use of antimicrobials and risk of type 1 diabetes in a population-based mother-child cohort.

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7.  Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation.

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8.  Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines.

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9.  Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53.

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10.  A prospective randomly controlled clinical trial on azithromycin therapy for induction treatment of children with nephrotic syndrome.

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