Literature DB >> 12604042

Clodronate liposomes: perspectives in research and therapeutics.

Nico van Rooijen1, Esther van Kesteren-Hendrikx.   

Abstract

Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.

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Year:  2002        PMID： 12604042     DOI： 10.1081/lpr-120004780

Source DB:  PubMed          Journal:  J Liposome Res        ISSN： 0898-2104            Impact factor:   3.648


  58 in total

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