| Literature DB >> 12593655 |
Clara Cena1, Marco L Lolli, Loretta Lazzarato, Elena Guaita, Giuseppina Morini, Gabriella Coruzzi, Stuart P McElroy, Ian L Megson, Roberta Fruttero, Alberto Gasco.
Abstract
A new series of NSAIDs in which aspirin is joined by an ester linkage to furoxan moieties, with different ability to release NO, were synthesized and tested for NO-releasing, antiinflammatory, antiaggregatory, and ulcerogenic properties. Related furazan derivatives, aspirin, its propyl ester, and its gamma-nitrooxypropyl ester were taken as references. All the products described present an antiinflammatory trend, maximized in derivatives 12, 16, and 17, they are devoid of acute gastrotoxicity, principally due to their ester nature, and show an antiplatelet activity primarily determined by their ability to release NO. They do not behave as aspirin prodrugs in human serum.Entities:
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Year: 2003 PMID： 12593655 DOI： 10.1021/jm020969t
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446