BACKGROUND: Recent studies found a relationship between Vitamin D and atherosclerosis. A common genetic polymorphism of the Vitamin D receptor (VDR) has been associated with coronary artery disease (CAD) in small study populations. To assess its influence on the prevalence and severity of CAD we studied a large-scale population. METHODS: A total of 3441 consecutive patients were referred for diagnostic coronary angiography. The BsmI Vitamin D receptor polymorphism was analyzed by polymerase chain reaction. Angiography was used to define phenotypes with clear coronary arteries (n = 775), coronary sclerosis (diameter stenosis < 50%; n = 579), CAD (diameter stenosis > 50% in at least one vessel; n = 1524). Patients with CAD at a young age (females aged less than 65 years, males aged less than 55 years; n = 563) were specially defined as premature CAD. The risk profile of traditional cardiovascular risk factors was obtained for every patient. RESULTS: The genotype frequencies of the VDR BsmI polymorphism did not differ between all four phenotypes (P = 0.756). The allele frequencies for the B allele were 0.43 vs. 0.44 vs. 0.42 vs. 0.45 in the four phenotypic groups (P = 0.827). All traditional cardiovascular risk factors (hypercholesterolaemia, smoking, hypertension, diabetes mellitus, severe obesity, male gender) were significantly (P < 0.001) associated with the angiographic phenotype. CONCLUSIONS: The VDR gene variant BsmI was not associated with prevalence and severity of CAD in a large-scale cohort phenotyped by angiography.
BACKGROUND: Recent studies found a relationship between Vitamin D and atherosclerosis. A common genetic polymorphism of the Vitamin D receptor (VDR) has been associated with coronary artery disease (CAD) in small study populations. To assess its influence on the prevalence and severity of CAD we studied a large-scale population. METHODS: A total of 3441 consecutive patients were referred for diagnostic coronary angiography. The BsmI Vitamin D receptor polymorphism was analyzed by polymerase chain reaction. Angiography was used to define phenotypes with clear coronary arteries (n = 775), coronary sclerosis (diameter stenosis < 50%; n = 579), CAD (diameter stenosis > 50% in at least one vessel; n = 1524). Patients with CAD at a young age (females aged less than 65 years, males aged less than 55 years; n = 563) were specially defined as premature CAD. The risk profile of traditional cardiovascular risk factors was obtained for every patient. RESULTS: The genotype frequencies of the VDR BsmI polymorphism did not differ between all four phenotypes (P = 0.756). The allele frequencies for the B allele were 0.43 vs. 0.44 vs. 0.42 vs. 0.45 in the four phenotypic groups (P = 0.827). All traditional cardiovascular risk factors (hypercholesterolaemia, smoking, hypertension, diabetes mellitus, severe obesity, male gender) were significantly (P < 0.001) associated with the angiographic phenotype. CONCLUSIONS: The VDR gene variant BsmI was not associated with prevalence and severity of CAD in a large-scale cohort phenotyped by angiography.
Authors: Jose C E Serrano; David De Lorenzo; Anna Cassanye; Meritxell Martín-Gari; Alberto Espinel; Marco Antonio Delgado; Reinald Pamplona; Manuel Portero-Otin Journal: Genes Nutr Date: 2013-09-25 Impact factor: 5.523
Authors: P Anagnostis; A Karagiannis; A I Kakafika; K Tziomalos; V G Athyros; D P Mikhailidis Journal: Osteoporos Int Date: 2008-05-29 Impact factor: 4.507
Authors: Patrick Linsel-Nitschke; Anika Götz; Jeanette Erdmann; Ingrid Braenne; Peter Braund; Christian Hengstenberg; Klaus Stark; Marcus Fischer; Stefan Schreiber; Nour Eddine El Mokhtari; Arne Schaefer; Jürgen Schrezenmeir; Jürgen Schrezenmeier; Diana Rubin; Anke Hinney; Thomas Reinehr; Christian Roth; Jan Ortlepp; Peter Hanrath; Alistair S Hall; Massimo Mangino; Wolfgang Lieb; Claudia Lamina; Iris M Heid; Angela Doering; Christian Gieger; Annette Peters; Thomas Meitinger; H-Erich Wichmann; Inke R König; Andreas Ziegler; Florian Kronenberg; Nilesh J Samani; Heribert Schunkert Journal: PLoS One Date: 2008-08-20 Impact factor: 3.240
Authors: Mark Lucock; Zoë Yates; Charlotte Martin; Jeong-Hwa Choi; Lyndell Boyd; Sa Tang; Nenad Naumovski; John Furst; Paul Roach; Nina Jablonski; George Chaplin; Martin Veysey Journal: Evol Med Public Health Date: 2014-04-02