Literature DB >> 12587970

Is inhalation rate important for a dry powder inhaler? Using the In-Check Dial to identify these rates.

H Chrystyn1.   

Abstract

The fraction of the emitted dose from an inhaler that has the potential to be deposited into the lungs is known as the fine particle dose (also the respirable dose). During inhalation all dry powder inhalers require a 'force' to be created inside the device so that a fine particle dose is generated from the formulation in the metering chamber. This 'force' is formed by the inhalation rate used together with the resistance (and hence design) inside an inhaler. Studies have shown that the fine particle dose is related to the clinical effect whilst other studies have reported that this dose can be dependent on the inhalation rate used. The inhalation technique recommended by the manufacturer of an inhaled device should, therefore, be used. For those dry powder inhalers that demonstrate significant flow dependent dosage emission it is important that patients use the most desirable rate that has been reported. The In-Check Dial is a simple and ease to use meter that can be used to measure the inhalation rate of a patient when they use each of the commonly prescribed inhalers that are currently available. This meter can be used to identify the most suitable inhaler for each individual.

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Year:  2003        PMID: 12587970     DOI: 10.1053/rmed.2003.1351

Source DB:  PubMed          Journal:  Respir Med        ISSN: 0954-6111            Impact factor:   3.415


  31 in total

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Authors:  Federico Lavorini; Pietro Geri; Martina Luperini; Nazzarena M Maluccio; Laura Mariani; Cecilia Marmai; Massimo Pistolesi; Giovanni A Fontana
Journal:  Br J Clin Pharmacol       Date:  2004-11       Impact factor: 4.335

Review 6.  Closer to an 'ideal inhaler' with the Easyhaler: an innovative dry powder inhaler.

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8.  Reduced Peak Inspiratory Effort through the Diskus((R)) and the Turbuhaler((R)) due to Mishandling is Common in Clinical Practice.

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9.  Spirometry Measurement of Peak Inspiratory Flow Identifies Suboptimal Use of Dry Powder Inhalers in Ambulatory Patients with COPD.

Authors:  Alexander G Duarte; Leon Tung; Wei Zhang; En Shuo Hsu; Yong-Fang Kuo; Gulshan Sharma
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10.  Rapid and Deep versus Normal Breathing in Salbutamol Inhalation Effectiveness; a Letter to Editor.

Authors:  Faeze Zeinali; Naser Mohammad Karimi; Mohamadali Jafari; Ebrahim Akbarzadeh Moghadam
Journal:  Arch Acad Emerg Med       Date:  2021-05-26
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