Calculation of steady-state distribution delay between central and peripheral compartments in two-compartment models with infusion regimen.

A lag time may exist between blood drug concentration and drug effect. Various factors can contribute to the lag time, among which the drug distribution delay is a significant one. The drug distribution delay can also exist between different compartments. An equation was derived to calculate the steady-state drug concentration delay between central and peripheral compartments in a two-compartment model with infusion regimen.