Sensitivity analysis of pharmacokinetic parameters in one-compartment models.

The quantitative properties of a compartmental model can be characterized by the pharmacokinetic parameters. The sensitivity analysis of pharmacokinetic parameters was studied in six kinds of one-compartment models. The sensitivity functions with respect to different pharmacokinetic parameters for these one-compartment models were deduced using the partial differentiation. The pharmacokinetic parameters were ranked according to their sensitivity functions. Copyright 2000 Academic Press.