Literature DB >> 1258610

Murine influenza virus encephalomyelitis. III. Effect of defective interfering virus particles.

E T Gamboa, D H Harter, P E Duffy, K C Hsu.   

Abstract

Defective interfering influenza virus particles lessened the yield of infective virus recovered from brain after intracerebral challange of 3-week old mice, but failed to affect the appearance of disease or lethality. In 7-week old mice, the presence of defective interfering influenza virus particles reduced both lethality and virus yield. Viral inocula containing significant numbers of defective particles appeared to diminish later inflammatory changes, nerve cell degeneration and the appearance of viral antigen in deeper cerebral regions. The protective effect exerted by defective virus particles does not appear related to interferon production in brain.

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Year:  1976        PMID： 1258610     DOI： 10.1007/BF00684666

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  23 in total

1.  DIFFERENCES IN INTERFERON CONTENT IN TISSUES OF MICE OF VARIOUS AGES INFECTED WITH COXSACKIE B1 VIRUS.

Authors:  H HEINEBERG; E GOLD; F C ROBBINS
Journal:  Proc Soc Exp Biol Med       Date:  1964-04

2.  A pantropic strain of influenza virus: generalized infection and viremia in the infant mouse.

Authors:  R R WAGNER
Journal:  Virology       Date:  1955-12       Impact factor: 3.616

3.  The limited growth of influenza viruses in the mouse brain.

Authors:  H J CAIRNS
Journal:  Aust J Exp Biol Med Sci       Date:  1954-02

4.  Incomplete growth cycle of influenza virus in mouse brain.

Authors:  R W SCHLESINGER
Journal:  Proc Soc Exp Biol Med       Date:  1950-07

Review 5.  Defective interfering viruses.

Authors:  A S Huang
Journal:  Annu Rev Microbiol       Date:  1973       Impact factor: 15.500

6.  Murine influenza virus encephalomyelitis. I. Neuropathological and immunofluorescence findings.

Authors:  K Miyoshi; A Wolf; D H Harter; P E Duffy; E T Gamboa; K C Hsu
Journal:  J Neuropathol Exp Neurol       Date:  1973-01       Impact factor: 3.685

7.  Antiviral activity of oxidized polyamines and aldehydes.

Authors:  L T Kremzner; D H Harter
Journal:  Biochem Pharmacol       Date:  1970-09       Impact factor: 5.858

8.  Replication of influenza virus in a continuous cell line: high yield of infective virus from cells inoculated at high multiplicity.

Authors:  P W Choppin
Journal:  Virology       Date:  1969-09       Impact factor: 3.616

9.  Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A-NWS (HON1) influenza virus.

Authors:  V Mayer; J L Schulman; E D Kilbourne
Journal:  J Virol       Date:  1973-02       Impact factor: 5.103

10.  Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.

Authors:  A H COONS; M H KAPLAN
Journal:  J Exp Med       Date:  1950-01-01       Impact factor: 14.307
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  1 in total

Review 1.  Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?

Authors:  Nigel J Dimmock; Andrew J Easton
Journal:  J Virol       Date:  2014-02-26       Impact factor: 5.103
  1 in total

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