Literature DB >> 125856

Is taurine-induced hypothermia in the rat mediated by 5-HT?

G P Sgaragli, F Pavàn, A Galli.   

Abstract

Intraventricular administration of taurine in the rat caused hypothermia, the extent of which was directly dependent upon the thermal gradient between the body and the environment. Pre-treatment of animals with p-chlorophenylalanine, which depleted most of the brain serotonin, strongly reduced the hypothermia induced by taurine. Pre-treatment with alpha-methyltyrosine induced hypothermia and sedation in animals. When this was followed by a taurine injection, they exhibited a decrease in body temperature which fitted the curve relating thermal gradients to hypothermic responses. It is suggested that taurine induced hypothermia in rat is mediated in part by central 5-HT systems.

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Year:  1975        PMID： 125856     DOI： 10.1007/bf00500525

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  A specific and sensitive enzymatic-isotopic microassay for serotonin in tissues.

Authors:  J M Saavedra; M Brownstein; J Axelrod
Journal:  J Pharmacol Exp Ther       Date:  1973-09       Impact factor: 4.030

2.  Effects of amino acid compounds injected into cerebrospinal fluid spaces, on colonic temperature, arterial blood pressure and behaviour of the rat.

Authors:  G Sgaragli; F Pavan
Journal:  Neuropharmacology       Date:  1972-01       Impact factor: 5.250

3.  p-Chlorophenylalanine: a specific depletor of brain serotonin.

Authors:  B K Koe; A Weissman
Journal:  J Pharmacol Exp Ther       Date:  1966-12       Impact factor: 4.030

4.  Effects of neutral aminoacids injected into cerebrospinal fluid space on glucose metabolism in the rat brain.

Authors:  G P Sgaragli; F Pavan
Journal:  Neuropharmacology       Date:  1973-07       Impact factor: 5.250

5.  Release of (3H)gamma-aminobutyric acid from glial cells in rat dorsal root ganglia.

Authors:  M C Minchin; L L Iversen
Journal:  J Neurochem       Date:  1974-09       Impact factor: 5.372

6.  On the role of glial cells in the mammalian nervous system. Uptake, excretion, and metabolism of putative neurotransmitters by cultured glial tumor cells.

Authors:  B K Schrier; E J Thompson
Journal:  J Biol Chem       Date:  1974-03-25       Impact factor: 5.157

7.  Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.

Authors:  E Jéquier; W Lovenberg; A Sjoerdsma
Journal:  Mol Pharmacol       Date:  1967-05       Impact factor: 4.436

8.  Temperature responses to monoamines and an inhibitor of MAO injected into the cerebral ventricles of rats.

Authors:  W Feldberg; V J Lotti
Journal:  Br J Pharmacol Chemother       Date:  1967-09

9.  Refillment of the catecholamine stores with 3,4-dihydroxyphenylalanine after depletion induced by inhibition of tyrosine-hydroxylase.

Authors:  H Corrodi; K Fuxe; T Hökfelt
Journal:  Life Sci       Date:  1966-04       Impact factor: 5.037
  9 in total
  3 in total

1.  Muscle relaxation induced in the rabbit by intracerebroventricular taurine injection: a supraspinal effect.

Authors:  G P Sgaragli; M Magnani; V Carlà; A Giotti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-10       Impact factor: 3.000

2.  Homotaurine and muscimol mimic taurine and GABA effects on muscle tone and temperature regulation.

Authors:  G P Sgaragli; V Carlà; M Magnani; A Giotti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-11       Impact factor: 3.000

3.  The effects of systemically administered taurine and N-pivaloyltaurine on striatal extracellular dopamine and taurine in freely moving rats.

Authors:  J Salimäki; G Scriba; T P Piepponen; N Rautolahti; L Ahtee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-07-26       Impact factor: 3.000
  3 in total

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