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Literature DB >> 12576658

O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans.

Abdel-Rahim Sayed Ibrahim¹, Ahmed Mohamed Galal, Mohammed Shamim Ahmed, Gabir Salem Mossa.

Abstract

Metabolism of 7-O-methylnaringenin (sakuranetin) by Cunninghamella elegans NRRL 1392 yielded naringenin and naringenin-4'-sulfate. C. elegans also converted 5, 3', 4'-trihydroxy-7-methoxyflavanone into eriodictyol-4'-sulfate. Furthermore, incubation of 5, 4'-dihydroxy-7, 3'-dimethoxyflavanone with the same fungus gave homoeriodictyol (5, 7, 4'-trihydroxy-3'-methoxyflavanone) and homoeriodicytol-7-sulfate. The structures of the new metabolites were established by spectral analysis including 2D-NMR, HR-ESI-FT-MS beside hydrolysis by acid.

Entities: Chemical Disease Species

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Year: 2003 PMID： 12576658 DOI： 10.1248/cpb.51.203

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

11 in total

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6. Protective Effect of Artemisia argyi and Its Flavonoid Constituents against Contrast-Induced Cytotoxicity by Iodixanol in LLC-PK1 Cells.

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O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans.

1. Biotransformation of Meloxicam by Cunninghamella blakesleeana: Significance of Carbon and Nitrogen Source.

2. Identification of sulfation sites of metabolites and prediction of the compounds' biological effects.

3. In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31.

4. Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells.

5. Improved oxidation of naringenin to carthamidin and isocarthamidin by Rhodotorula marina.

6. Protective Effect of Artemisia argyi and Its Flavonoid Constituents against Contrast-Induced Cytotoxicity by Iodixanol in LLC-PK1 Cells.

7. Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP-Glucuronosyltransferases.

8. Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica.

9. Microbial transformations of 7-methoxyflavanone.

Review 10. A Review on Sources and Pharmacological Aspects of Sakuranetin.