| Literature DB >> 12575832 |
Matthias Endres1, Ulrich Dirnagl.
Abstract
Cell death following cerebral ischemia is mediated by a complex pathophysiologic interaction of different mechanisms. In this Chapter we will outline the basic principles as well as introduce in vitro and in vivo models of cerebral ischemia. Mechanistically, excitotoxicity, peri-infarct depolarization, inflammation and apoptosis seem to be the most relevant mediators of damage and are promising targets for neuroprotective strategies.Entities:
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Year: 2002 PMID: 12575832 DOI: 10.1007/978-1-4615-0123-7_17
Source DB: PubMed Journal: Adv Exp Med Biol ISSN: 0065-2598 Impact factor: 2.622