Literature DB >> 12573434

RUNX transcription factors as key targets of TGF-beta superfamily signaling.

Yoshiaki Ito1, Kohei Miyazono.   

Abstract

The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.

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Year:  2003        PMID： 12573434     DOI： 10.1016/s0959-437x(03)00007-8

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  98 in total

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6.  Tumor suppressor function of RUNX3 in breast cancer.

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8.  Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis.

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9.  Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.

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Review 10.  Signaling and transcriptional regulation in osteoblast commitment and differentiation.

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