Kiren Handa1, Nancy Kreiger. 1. Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Abstract
OBJECTIVES: Our objective was to identify food intake patterns that might be associated with the risk of renal cell carcinoma. DESIGN: A total of 461 cases (210 females, 251 males) were age frequency matched to population controls. Diet factors were created using factor analysis of 69 food items from a food-frequency questionnaire. These factors were modelled using logistic regression to identify those associated with renal cell carcinoma. SETTING: We investigated the role of diet in the aetiology of renal cell carcinoma using a population-based case--control study conducted in Ontario between 1995 and 1996. SUBJECTS: Cases were Ontario residents 20 to 74 years of age identified through review of pathology reports in the Ontario Cancer Registry. RESULTS: A 'dessert' diet factor was positively associated with disease for both sexes (odds ratio estimate (OR) for males = 3.7, 95% confidence interval (CI) 2.0-6.9; OR for females = 1.4, 95% CI 0.8-2.2, for the highest vs. lowest quartile). In males, a 'beef' diet factor was identified and was associated with an increased risk of renal cell carcinoma. Furthermore, a 'juices' diet factor also showed an association with increased risk in males (OR = 1.8, 95% CI 1.0-3.1). For females, a positive association was observed between renal cell carcinoma and an 'unhealthy' diet factor (OR = 1.4, 95% CI 0.8-2.4). CONCLUSIONS: Our findings confirmed that high-fat and high-protein diets might be risk factors for renal cell carcinoma. The data also suggest an increased risk associated with juice intake, a finding not previously reported.
OBJECTIVES: Our objective was to identify food intake patterns that might be associated with the risk of renal cell carcinoma. DESIGN: A total of 461 cases (210 females, 251 males) were age frequency matched to population controls. Diet factors were created using factor analysis of 69 food items from a food-frequency questionnaire. These factors were modelled using logistic regression to identify those associated with renal cell carcinoma. SETTING: We investigated the role of diet in the aetiology of renal cell carcinoma using a population-based case--control study conducted in Ontario between 1995 and 1996. SUBJECTS: Cases were Ontario residents 20 to 74 years of age identified through review of pathology reports in the Ontario Cancer Registry. RESULTS: A 'dessert' diet factor was positively associated with disease for both sexes (odds ratio estimate (OR) for males = 3.7, 95% confidence interval (CI) 2.0-6.9; OR for females = 1.4, 95% CI 0.8-2.2, for the highest vs. lowest quartile). In males, a 'beef' diet factor was identified and was associated with an increased risk of renal cell carcinoma. Furthermore, a 'juices' diet factor also showed an association with increased risk in males (OR = 1.8, 95% CI 1.0-3.1). For females, a positive association was observed between renal cell carcinoma and an 'unhealthy' diet factor (OR = 1.4, 95% CI 0.8-2.4). CONCLUSIONS: Our findings confirmed that high-fat and high-protein diets might be risk factors for renal cell carcinoma. The data also suggest an increased risk associated with juice intake, a finding not previously reported.
Authors: Kaye E Brock; Gloria Gridley; Brian C-H Chiu; Abby G Ershow; Charles F Lynch; Kenneth P Cantor Journal: Br J Nutr Date: 2008-09-12 Impact factor: 3.718
Authors: Stephanie C Melkonian; Carrie R Daniel; Michelle A T Hildebrandt; Nizar M Tannir; Yuanqing Ye; Wong-Ho Chow; Christopher G Wood; Xifeng Wu Journal: Am J Epidemiol Date: 2014-07-22 Impact factor: 4.897
Authors: Monica Bertoia; Demetrius Albanes; Susan T Mayne; Satu Männistö; Jarmo Virtamo; Margaret E Wright Journal: Int J Cancer Date: 2010-03-15 Impact factor: 7.396
Authors: Lisa Langsetmo; Suzette Poliquin; David A Hanley; Jerilynn C Prior; Susan Barr; Tassos Anastassiades; Tanveer Towheed; David Goltzman; Nancy Kreiger Journal: BMC Musculoskelet Disord Date: 2010-01-28 Impact factor: 2.362
Authors: Ambika Satija; Frank B Hu; Liza Bowen; Ankalmadugu V Bharathi; Mario Vaz; Dorairaj Prabhakaran; K Srinath Reddy; Yoav Ben-Shlomo; George Davey Smith; Sanjay Kinra; Shah Ebrahim Journal: Public Health Nutr Date: 2015-02-20 Impact factor: 4.022