| Literature DB >> 12565968 |
Scott H Watterson1, Marianne Carlsen, T G Murali Dhar, Zhongqi Shen, William J Pitts, Junqing Guo, Henry H Gu, Derek Norris, John Chorba, Ping Chen, Daniel Cheney, Mark Witmer, Catherine A Fleener, Katherine Rouleau, Robert Townsend, Diane L Hollenbaugh, Edwin J Iwanowicz.
Abstract
A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.Entities:
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Year: 2003 PMID： 12565968 DOI： 10.1016/s0960-894x(02)00944-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823