| Literature DB >> 12565954 |
Colin M Tice1, Robert E Hormann, Christine S Thompson, Jennifer L Friz, Caitlin K Cavanaugh, Enrique L Michelotti, Javier Garcia, Ernesto Nicolas, Fernando Albericio.
Abstract
A lead discovery library and a follow-up focused library of alpha-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS(TM)-E. The compounds were assayed in mammalian cells expressing the ecdysone receptor from Bombyx mori for their ability to cause expression of a reporter gene downstream of an ecdysone response element. The most potent alpha-acylaminoketones were comparable to GS(TM)-E in this assay.Entities:
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Year: 2003 PMID： 12565954 DOI： 10.1016/s0960-894x(02)00980-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823