[Hyperthermia induced signal for apoptosis and pathways of its transduction in the cell].

Hyperthermia (HT) is a physiological agent able to induce apoptosis in normal and tumor cells. The ability of HT to damage different cellular components is underlying the mechanism of apoptogenic activity of HT. The review is aimed to consider the studies representing mainly HT production of genotoxic initial signal and pathways of its transduction to programmed cytotoxic event or apoptosis. In this regard we analyse the membrane effect of HT, HT-induced chromatin and nuclear matrix structure changes, DNA damage, effect of HT on DNA-repair mechanism, and the role of heat shock proteins in apoptosis and cancerogenesis.