Literature DB >> 12559684

A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans.

Bonnie A Thiel1, Aravinda Chakravarti, Richard S Cooper, Amy Luke, Sue Lewis, Audrey Lynn, Hemant Tiwari, Nicholas J Schork, Alan B Weder.   

Abstract

Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large. Copyright 2003 American Journal of Hypertension, Ltd.

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Year:  2003        PMID： 12559684     DOI： 10.1016/s0895-7061(02)03246-6

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN： 0895-7061            Impact factor:   2.689


  18 in total

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Journal:  Mol Neurobiol       Date:  2013-10-10       Impact factor: 5.590

4.  Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

Authors:  Georg B Ehret; Ashley A O'Connor; Alan Weder; Richard S Cooper; Aravinda Chakravarti
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5.  A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.

Authors:  Sue Rutherford; Guowen Cai; Juan C Lopez-Alvarenga; Jack W Kent; V Saroja Voruganti; J Michael Proffitt; Joanne E Curran; Mathew P Johnson; Thomas D Dyer; Jeremy B Jowett; Raul A Bastarrachea; Larry D Atwood; Harald H H Goring; Jean W Maccluer; Eric K Moses; John Blangero; Anthony G Comuzzie; Shelley A Cole
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Review 6.  Genetic architecture of complex traits predisposing to nephropathy: hypertension.

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7.  Voluntary participation and informed consent to international genetic research.

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Review 8.  Genetics of arterial hypertension and hypotension.

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Review 9.  Hypertension in young children and neonates.

Authors:  John Edward Jones; Pedro A Jose
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10.  Positional identification of variants of Adamts16 linked to inherited hypertension.

Authors:  Bina Joe; Yasser Saad; Seema Dhindaw; Norman H Lee; Bryan C Frank; Ovokeraye H Achinike; Truong V Luu; Kathirvel Gopalakrishnan; Edward J Toland; Phyllis Farms; Shane Yerga-Woolwine; Ezhilarasi Manickavasagam; John P Rapp; Michael R Garrett; David Coe; Suneel S Apte; Tuomo Rankinen; Louis Pérusse; Georg B Ehret; Santhi K Ganesh; Richard S Cooper; Ashley O'Connor; Treva Rice; Alan B Weder; Aravinda Chakravarti; Dabeeru C Rao; Claude Bouchard
Journal:  Hum Mol Genet       Date:  2009-05-07       Impact factor: 6.150
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