Literature DB >> 12559683

A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network.

Dabeeru C Rao1, Michael A Province, Mark F Leppert, A l Oberman, Gerardo Heiss, R Curt Ellison, Donna K Arnett, John H Eckfeldt, Karen Schwander, Steve C Mockrin, Steve C Hunt.   

Abstract

Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes. Copyright 2003 American Journal of Hypertension, Ltd.

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Year:  2003        PMID： 12559683     DOI： 10.1016/s0895-7061(02)03247-8

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN： 0895-7061            Impact factor:   2.689


  22 in total

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8.  Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study.

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9.  Genetic and environmental risks for high blood pressure among African American mothers and daughters.

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10.  Microsatellites and SNPs linkage analysis in a Sardinian genetic isolate confirms several essential hypertension loci previously identified in different populations.

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Journal:  BMC Med Genet       Date:  2009-08-28       Impact factor: 2.103
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