Literature DB >> 12557910

Hypoglycemic effect of aqueous extract of Enicostemma littorale Blume (chhota chirayata) on alloxan induced diabetes mellitus in rats.

R Vijayvargia1, M Kumar, S Gupta.   

Abstract

The whole plant aqueous extract of E. littorale was tested for its hypoglycemic activity on normoglycemic, hyperglycemic and alloxan induced diabetic rats. Blood sugar lowering activity was not observed in normoglycemic and glucose loaded hyperglycemic rats in the short time experiment. But in case of diabetic rats, the fall of blood sugar after 30 days treatment with the aqueous extract was found to be significant (P < 0.001). The decrease in the plasma glucose level was accompanied with decrease in the level of glycosylated haemoglobin and glucose-6-phosphatase activity in liver. The potent anti-diabetic properties of E. littorale has been reported for the first time.

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Year:  2000        PMID: 12557910

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN: 0019-5189            Impact factor:   0.818


  7 in total

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Journal:  J Endocrinol Invest       Date:  2015-03-15       Impact factor: 4.256

3.  Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus.

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Journal:  In Silico Pharmacol       Date:  2021-12-02

4.  Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.

Authors:  Hitesh Vaidya; Mandapati Rajani; Vasudevan Sudarsanam; Harish Padh; Ramesh Goyal
Journal:  J Nat Med       Date:  2009-07-25       Impact factor: 2.343

5.  Antiulcer and Anti-inflammatory Activity of Aerial Parts Enicostemma littorale Blume.

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6.  Indian herbs and herbal drugs used for the treatment of diabetes.

Authors:  Manisha Modak; Priyanjali Dixit; Jayant Londhe; Saroj Ghaskadbi; Thomas Paul A Devasagayam
Journal:  J Clin Biochem Nutr       Date:  2007-05       Impact factor: 3.114

7.  A Small Molecule Swertisin from Enicostemma littorale Differentiates NIH3T3 Cells into Islet-Like Clusters and Restores Normoglycemia upon Transplantation in Diabetic Balb/c Mice.

Authors:  Nidheesh Dadheech; Sanket Soni; Abhay Srivastava; Sucheta Dadheech; Shivika Gupta; Renjitha Gopurappilly; Ramesh R Bhonde; Sarita Gupta
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-15       Impact factor: 2.629

  7 in total

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