| Literature DB >> 19633811 |
Hitesh Vaidya1, Mandapati Rajani, Vasudevan Sudarsanam, Harish Padh, Ramesh Goyal.
Abstract
We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid levels such as total cholesterol, triglycerides and low-density lipoprotein cholesterol increased significantly (P < 0.001) compared with normal control rats. All these changes were significantly prevented in the rats treated with swertiamarin. Serum high-density lipoprotein (HDL) cholesterol was found to be reduced in the P-407 control rats. However, administration of swertiamarin significantly (P < 0.01) increased HDL levels and it showed a significant lipid-lowering effect, as well as a high antiatherogenic potential. Overall swertiamarin is an effective lipid-lowering lead compound and can be useful for preventing atherosclerosis.Entities:
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Year: 2009 PMID： 19633811 DOI： 10.1007/s11418-009-0350-8
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343