Literature DB >> 12557295

Magnetic resonance imaging and neurosphere therapy of stroke in rat.

Zheng Gang Zhang1, Quan Jiang, Ruilan Zhang, Li Zhang, Lei Wang, Lijei Zhang, Polly Arniego, Khang-Loon Ho, Michael Chopp.   

Abstract

We intracisternally transplanted subventricular zone (SVZ) cells labeled by ferromagnetic particles into stroked rats. Migration of transplanted cells was non-invasively tracked using magnetic resonance imaging (MRI). We found that transplanted cells selectively migrated towards the ischemic parenchyma at a mean speed of 65 +/- 14.6 microm/hr in living rats. Migration of transplanted cells in the brain was also measured histopathologically. Rats transplanted with SVZ cells exhibited significant improvement of neurological function. Our data suggest that intracisternal transplantation of SVZ cells provides an avenue for cell therapy of stroke and that MRI can be used to track grafted cells in the brain.

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Year:  2003        PMID： 12557295     DOI： 10.1002/ana.10467

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  44 in total

1.  Quantitative analysis of neural stem cell migration and tracer clearance in the rat brain by MRI.

Authors:  Jennifer A Flexman; Donna J Cross; Linh N Tran; Takahiro Sasaki; Yongmin Kim; Satoshi Minoshima
Journal:  Mol Imaging Biol       Date:  2011-02       Impact factor: 3.488

Review 2.  Cell-based therapy for stroke.

Authors:  Yu Luo
Journal:  J Neural Transm (Vienna)       Date:  2010-10-14       Impact factor: 3.575

3.  In vivo Tracking of Transplanted Bone Marrow-Derived Mesenchymal Stem Cells in a Murine Model of Stroke by Bioluminescence Imaging.

Authors:  Kyung-Sool Jang; Kwan-Sung Lee; Seung-Ho Yang; Sin-Soo Jeun
Journal:  J Korean Neurosurg Soc       Date:  2010-11-30

4.  Cell labeling with the positive MR contrast agent Gadofluorine M.

Authors:  Tobias D Henning; Olaf Saborowski; Daniel Golovko; Sophie Boddington; Jan S Bauer; Yanjun Fu; Reinhard Meier; Hubertus Pietsch; Barbara Sennino; Donald M McDonald; Heike E Daldrup-Link
Journal:  Eur Radiol       Date:  2007-01-06       Impact factor: 5.315

5.  Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia.

Authors:  Piotr Walczak; Jian Zhang; Assaf A Gilad; Dorota A Kedziorek; Jesus Ruiz-Cabello; Randell G Young; Mark F Pittenger; Peter C M van Zijl; Judy Huang; Jeff W M Bulte
Journal:  Stroke       Date:  2008-03-06       Impact factor: 7.914

Review 6.  Stem cell therapy: MRI guidance and monitoring.

Authors:  Dara L Kraitchman; Wesley D Gilson; Christine H Lorenz
Journal:  J Magn Reson Imaging       Date:  2008-02       Impact factor: 4.813

Review 7.  Cell tracking using magnetic resonance imaging.

Authors:  Mathias Hoehn; Dirk Wiedermann; Carles Justicia; Pedro Ramos-Cabrer; Klaus Kruttwig; Tracy Farr; Uwe Himmelreich
Journal:  J Physiol       Date:  2007-08-09       Impact factor: 5.182

8.  Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.

Authors:  Marcel M Daadi; Zongjin Li; Ahmet Arac; Brad A Grueter; Marc Sofilos; Robert C Malenka; Joseph C Wu; Gary K Steinberg
Journal:  Mol Ther       Date:  2009-05-12       Impact factor: 11.454

9.  A chronic 1 year assessment of MRI contrast agent-labelled neural stem cell transplants in stroke.

Authors:  M Modo; J S Beech; T J Meade; S C R Williams; J Price
Journal:  Neuroimage       Date:  2008-06-25       Impact factor: 6.556

10.  Validity of bone marrow stromal cell expansion by animal serum-free medium for cell transplantation therapy of cerebral infarct in rats-a serial MRI study.

Authors:  Masaki Ito; Satoshi Kuroda; Taku Sugiyama; Hideo Shichinohe; Yukari Takeda; Mitsufumi Nishio; Takao Koike; Kiyohiro Houkin
Journal:  Transl Stroke Res       Date:  2011-07-26       Impact factor: 6.829
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