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Literature DB >> 12554937

Actin-DBP: the perfect structural fit?

Christel Verboven¹, Ilse Bogaerts, Etienne Waelkens, Anja Rabijns, Hugo Van Baelen, Roger Bouillon, Camiel De Ranter.

Abstract

The multifunctional vitamin D binding protein (DBP) is an actin-sequestering protein present in blood. The crystal structure of the actin-DBP complex was determined at 2.4 A resolution. DBP binds to actin subdomains 1 and 3 and occludes the cleft at the interface between these subdomains. Most remarkably, DBP demonstrates an unusually large actin-binding interface, far exceeding the binding-interface areas reported for other actin-binding proteins such as profilin, DNase I and gelsolin. The fast-growing side of actin monomers is blocked completely through a perfect structural fit with DBP, demonstrating how DBP effectively interferes with actin-filament formation. It establishes DBP as the hitherto best actin-sequestering protein and highlights its key role in suppressing and preventing extracellular actin polymerization.

Entities: Gene Species

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Year: 2003 PMID： 12554937 DOI： 10.1107/s0907444902021455

Source DB: PubMed Journal: Acta Crystallogr D Biol Crystallogr ISSN： 0907-4449

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Cited

8 in total

1. A nucleotide state-sensing region on actin.

Authors: Dmitri S Kudryashov; Elena E Grintsevich; Peter A Rubenstein; Emil Reisler
Journal: J Biol Chem Date: 2010-06-08 Impact factor: 5.157

2. Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D.

Authors: Arjun Ray; Narasimha Swamy; Rahul Ray
Journal: Biochem Biophys Res Commun Date: 2007-11-21 Impact factor: 3.575

3. Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.

Authors: Glenda Trujillo; David M Habiel; Lingyin Ge; Mahalakshmi Ramadass; Nancy E Cooke; Richard R Kew
Journal: J Immunol Date: 2013-06-10 Impact factor: 5.422

4. Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children.

Authors: K M Palframan; S L Robinson; M Mora-Plazas; C Marin; E Villamor
Journal: Epidemiol Infect Date: 2018-07-30 Impact factor: 4.434

Actin-DBP: the perfect structural fit?

1. A nucleotide state-sensing region on actin.

2. Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D.

3. Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.

4. Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children.

Review 5. Hypovitaminosis D: Is It Time to Consider the Use of Calcifediol?

6. The Origins of Salivary Vitamin A, Vitamin B₁₂ and Vitamin D-Binding Proteins.

Review 7. Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton.

8. Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

Actin-DBP: the perfect structural fit?

1. A nucleotide state-sensing region on actin.

2. Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D.

3. Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.

4. Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children.

Review 5. Hypovitaminosis D: Is It Time to Consider the Use of Calcifediol?

6. The Origins of Salivary Vitamin A, Vitamin B12 and Vitamin D-Binding Proteins.

Review 7. Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton.

8. Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

6. The Origins of Salivary Vitamin A, Vitamin B₁₂ and Vitamin D-Binding Proteins.