AIMS AND METHODS: Magnetic resonance imaging (MRI) of the hippocampus has been extensively studied in both neurological and psychiatric disorders. Furthermore, hippocampal volume reductions on MRI have been reported in patients with chronic alcoholism. The present volumetric MRI study was undertaken to determine whether an association exists between hippocampal volume reduction and first-onset alcohol withdrawal seizure. Until recently, no data as to whether hippocampal volume reductions in alcoholics might serve as a predictor of withdrawal seizures were available. RESULTS: We found the average hippocampal volumes measured by high resolution MRI to be significantly reduced in 52 alcoholics compared with 30 healthy controls. Besides a decrease of hippocampal volume in patients with chronic alcoholism, we could not find any significant correlation between the occurrence of seizures during alcohol withdrawal and the amount of hippocampal volume reduction in these patients. CONCLUSIONS: Thus, the alcoholism-related atrophy within the hippocampal formation in patients suffering from chronic alcoholism does not seem to be the source of convulsive activity in these patients. Neither does the amount of atrophy allow the occurrence of first-onset withdrawal seizures to be predicted.
AIMS AND METHODS: Magnetic resonance imaging (MRI) of the hippocampus has been extensively studied in both neurological and psychiatric disorders. Furthermore, hippocampal volume reductions on MRI have been reported in patients with chronic alcoholism. The present volumetric MRI study was undertaken to determine whether an association exists between hippocampal volume reduction and first-onset alcohol withdrawal seizure. Until recently, no data as to whether hippocampal volume reductions in alcoholics might serve as a predictor of withdrawal seizures were available. RESULTS: We found the average hippocampal volumes measured by high resolution MRI to be significantly reduced in 52 alcoholics compared with 30 healthy controls. Besides a decrease of hippocampal volume in patients with chronic alcoholism, we could not find any significant correlation between the occurrence of seizures during alcohol withdrawal and the amount of hippocampal volume reduction in these patients. CONCLUSIONS: Thus, the alcoholism-related atrophy within the hippocampal formation in patients suffering from chronic alcoholism does not seem to be the source of convulsive activity in these patients. Neither does the amount of atrophy allow the occurrence of first-onset withdrawal seizures to be predicted.
Authors: Stefan Gazdzinski; Timothy C Durazzo; Ping-Hong Yeh; Dawn Hardin; Peter Banys; Dieter J Meyerhoff Journal: Psychiatry Res Date: 2008-02-28 Impact factor: 3.222
Authors: A Uhlmann; B Bandelow; D J Stein; S Bloch; K R Engel; U Havemann-Reinecke; Dirk Wedekind Journal: Eur Arch Psychiatry Clin Neurosci Date: 2018-01-25 Impact factor: 5.270
Authors: Sudha Seshadri; Philip A Wolf; Alexa S Beiser; Jacob Selhub; Rhoda Au; Paul F Jacques; Mitsuhiro Yoshita; Irwin H Rosenberg; Ralph B D'Agostino; Charles DeCarli Journal: Arch Neurol Date: 2008-05
Authors: Anne Lise Pitel; Hélène Beaunieux; Thomas Witkowski; François Vabret; Bérengère Guillery-Girard; Peggy Quinette; Béatrice Desgranges; Francis Eustache Journal: Alcohol Clin Exp Res Date: 2007-05-20 Impact factor: 3.455