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Literature DB >> 12550736

GABA(A) receptor function and pharmacology in epilepsy and status epilepticus.

Dorothy M Jones-Davis¹, Robert L Macdonald.

Abstract

GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2003 PMID： 12550736 DOI： 10.1016/s1471-4892(02)00015-2

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

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Cited

24 in total

Review 1. Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

Authors: Renê Oliveira Beleboni; Ruither Oliveira Gomes Carolino; Andrea Baldocchi Pizzo; Lissandra Castellan-Baldan; Joaquim Coutinho-Netto; Wagner Ferreira dos Santos; Norberto Cysne Coimbra
Journal: Cell Mol Neurobiol Date: 2004-12 Impact factor: 5.046

Review 2. Modulating inhibitory ligand-gated ion channels.

Authors: Michael Cascio
Journal: AAPS J Date: 2006-05-26 Impact factor: 4.009

3. Homology modeling and molecular dynamics simulations of the glycine receptor ligand binding domain.

Authors: Kirill Speranskiy; Michael Cascio; Maria Kurnikova
Journal: Proteins Date: 2007-06-01

4. Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.

Authors: Lia C Liefaard; Bart A Ploeger; Carla F M Molthoff; Ronald Boellaard; Adriaan A Lammertsma; Meindert Danhof; Rob A Voskuyl
Journal: Mol Imaging Biol Date: 2005 Nov-Dec Impact factor: 3.488

Review 5. Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor.

Authors: Gustav Akk; Joe Henry Steinbach
Journal: Anesthesiology Date: 2011-12 Impact factor: 7.892

6. Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing.

Authors: Xi Zhang; Keith W Miller
Journal: Mol Cell Proteomics Date: 2014-12-03 Impact factor: 5.911

GABA(A) receptor function and pharmacology in epilepsy and status epilepticus.

Review 1. Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

Review 2. Modulating inhibitory ligand-gated ion channels.

3. Homology modeling and molecular dynamics simulations of the glycine receptor ligand binding domain.

4. Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.

Review 5. Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor.

6. Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing.

Review 7. Ion channels as drug targets in central nervous system disorders.

8. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes.

Review 9. Out of thin air: Hyperventilation-triggered seizures.

Review 10. Molecular mechanisms of antiseizure drug activity at GABAA receptors.