Alan H Jobe1, John P Newnham, Timothy J Moss, Machiko Ikegami. 1. Division of Pulmonary Biology, Cincinnati Children's Hospital, and the School of Women's and Infant's Health, University of Western Australia. alan.jobe@chmcc.org
Abstract
OBJECTIVES: We asked whether maternal or fetal cortisol treatments induced fetal lung maturation and growth restriction compared with betamethasone and whether medroxyprogesterone (MPA) influenced lung maturation. STUDY DESIGN: Pregnant sheep were randomized to receive MPA or saline solution at 100 days of gestation. At 117 days of pregnancy, ewes were randomized to receive maternal or fetal treatments with 0.5 mg/kg betamethasone, four injections of hydrocortisone given over 4.5 hours or saline solution. Body weight and lung maturation were evaluated at 125 days. RESULTS: Maternal betamethasone decreased in birth weight by 16% and induced lung maturation. Fetal cortisol or betamethasone induced only lung maturation. Maternal cortisol caused neither growth restriction nor lung maturation. MPA did not alter lung function in control lambs or in betamethasone-treated preterm lambs. CONCLUSIONS: Maternal cortisol treatments had no apparent effects on the fetus, suggesting that growth restriction caused by betamethasone may result from unidentified effects on the maternal-placental unit.
OBJECTIVES: We asked whether maternal or fetal cortisol treatments induced fetal lung maturation and growth restriction compared with betamethasone and whether medroxyprogesterone (MPA) influenced lung maturation. STUDY DESIGN: Pregnant sheep were randomized to receive MPA or saline solution at 100 days of gestation. At 117 days of pregnancy, ewes were randomized to receive maternal or fetal treatments with 0.5 mg/kg betamethasone, four injections of hydrocortisone given over 4.5 hours or saline solution. Body weight and lung maturation were evaluated at 125 days. RESULTS: Maternal betamethasone decreased in birth weight by 16% and induced lung maturation. Fetal cortisol or betamethasone induced only lung maturation. Maternal cortisol caused neither growth restriction nor lung maturation. MPA did not alter lung function in control lambs or in betamethasone-treated preterm lambs. CONCLUSIONS: Maternal cortisol treatments had no apparent effects on the fetus, suggesting that growth restriction caused by betamethasone may result from unidentified effects on the maternal-placental unit.
Authors: Elke Kuypers; Jennifer J P Collins; Boris W Kramer; Gaston Ofman; Ilias Nitsos; J Jane Pillow; Graeme R Polglase; Matthew W Kemp; John P Newnham; Antonio W D Gavilanes; Relana Nowacki; Machiko Ikegami; Alan H Jobe; Suhas G Kallapur Journal: Am J Physiol Lung Cell Mol Physiol Date: 2011-12-09 Impact factor: 5.464
Authors: Katherine B Wolfe; Candice C Snyder; Tate Gisslen; Matthew W Kemp; John P Newnham; Boris W Kramer; Alan H Jobe; Suhas Kallapur Journal: Reprod Sci Date: 2013-05-07 Impact factor: 3.060
Authors: Jessica R Crawshaw; Stuart B Hooper; Arjan B Te Pas; Beth A Allison; Megan J Wallace; Lauren T Kerr; Robert A Lewis; Colin J Morley; Andrew F Leong; Marcus J Kitchen Journal: J Appl Physiol (1985) Date: 2016-07-08
Authors: Alan H Jobe; Timothy J M Moss; Ilias Nitsos; Machiko Ikegami; Suhas G Kallapur; John P Newnham Journal: Am J Obstet Gynecol Date: 2007-11 Impact factor: 8.661