[Effect of 5 polycyclic aromatic hydrocarbons on estrogen receptor binding in rats].

The estrogenic activity of 5 polycyclic aromatic hydrocarbons(PAHs) of rat uterine wet weight bioassy and estrogen receptor binding bioassy are determined. The results show that penzo(a)pyrene, 7,12-dimethyl benz(a)anthracene and pentacene could statistically increase uterine wet weight of immature female rats(P < 0.01 or P < 0.05) while benz(a)anthracene and chrysene can not significantly increase uterine wet weight(P > 0.05). Penzo(a)pyrene, 7,12-dimethyl benz(a)anthracene and pentacene effectively inhibit the specific 3H-estradial binding to rat uterine estrogen receptor(P < 0.01). Whereas benz(a)anthracene and chrysene can not inhibit the specific 3H-estradial binding to rat uterine estrogen receptor(P > 0.05). The results from this study indicate that penzo(a)pyrene, 7,12-dimethyl benz(a) anthracene and pentacene have significant estrogenic activity.