Literature DB >> 12543936

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

Masaru Taniguchi1, Michishige Harada, Satoshi Kojo, Toshinori Nakayama, Hiroshi Wakao.   

Abstract

A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.

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Year:  2001        PMID： 12543936     DOI： 10.1146/annurev.immunol.21.120601.141057

Source DB:  PubMed          Journal:  Annu Rev Immunol        ISSN： 0732-0582            Impact factor:   28.527


  234 in total

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