Literature DB >> 12543263

Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment.

Michela Gallagher1, Jennifer L Bizon, Eileen C Hoyt, Katherine A Helm, Pauline K Lund.   

Abstract

Vertical integration is being used to great advantage in neurobiological research on the basis of age-related cognitive decline. Such research bridges analysis between the molecular and cellular levels and the outcome of impaired psychological functions. Current use of animals models within this paradigm has defined mild cognitive impairment in a subpopulation of outbred aged Long-Evans rats by assessment of hippocampal-dependent spatial cognition. Aged rats with cognitive impairment exhibited no loss of neurons in the hippocampus. Current research is focused on the functional alterations in neurons by methods which assess transcriptional mechanisms and signaling pathways.

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Mesh：

Year:  2003        PMID： 12543263     DOI： 10.1016/s0531-5565(02)00159-6

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  39 in total

1.  Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.

Authors:  Ming Teng Koh; Sharon Rosenzweig-Lipson; Michela Gallagher
Journal:  Neuropharmacology       Date:  2012-06-23       Impact factor: 5.250

2.  Greater loss of object than spatial mnemonic discrimination in aged adults.

Authors:  Zachariah M Reagh; Huy D Ho; Stephanie L Leal; Jessica A Noche; Amanda Chun; Elizabeth A Murray; Michael A Yassa
Journal:  Hippocampus       Date:  2016-01-18       Impact factor: 3.899

3.  Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys.

Authors:  Yuko Hara; C Sehwan Park; William G M Janssen; Mary T Roberts; John H Morrison; Peter R Rapp
Journal:  Neurobiol Aging       Date:  2010-10-27       Impact factor: 4.673

Review 4.  A meeting to remember: meeting on memory and related disorders.

Authors:  Gregory P Gasic; Angel Barco; Jesús Avila; Juan Lerma
Journal:  EMBO Rep       Date:  2006-07-14       Impact factor: 8.807

5.  Social recognition memory: influence of age, sex, and ovarian hormonal status.

Authors:  Julie A Markham; Janice M Juraska
Journal:  Physiol Behav       Date:  2007-07-03

6.  Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity.

Authors:  Christy S Carter; Christiaan Leeuwenburgh; Michael Daniels; Thomas C Foster
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-05-06       Impact factor: 6.053

7.  Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Authors:  Inga Kadish; Olivier Thibault; Eric M Blalock; Kuey-C Chen; John C Gant; Nada M Porter; Philip W Landfield
Journal:  J Neurosci       Date:  2009-02-11       Impact factor: 6.167

8.  Relationship between mRNA expression of splice forms of the zeta1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice.

Authors:  Siba R Das; Kathy R Magnusson
Journal:  Brain Res       Date:  2008-02-29       Impact factor: 3.252

9.  An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory.

Authors:  H Eichenbaum; N Fortin; M Sauvage; R J Robitsek; A Farovik
Journal:  Neuropsychologia       Date:  2009-09-20       Impact factor: 3.139

10.  Head west or left, east or right: interactions between memory systems in neurocognitive aging.

Authors:  Inês Tomás Pereira; Michela Gallagher; Peter R Rapp
Journal:  Neurobiol Aging       Date:  2015-07-26       Impact factor: 4.673
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