| Literature DB >> 12542491 |
Masahiro Kami1, Tamae Hamaki, Shigesaburo Miyakoshi, Naoko Murashige, Yoshinobu Kanda, Ryuji Tanosaki, Yoichi Takaue, Shuichi Taniguchi, Hisamaru Hirai, Keiya Ozawa, Masaharu Kasai.
Abstract
The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 +/- 30% and 45 +/- 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.Entities:
Mesh：
Year: 2003 PMID： 12542491 DOI： 10.1046/j.1365-2141.2003.04054.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998