Literature DB >> 15353320

Adult T cell leukemia lymphoma.

Lee Ratner1.   

Abstract

Adult T cell leukemia lymphoma (ATLL) is a CD4+ lymphoproliferative malignancy resulting from human T-cell leukemia virus type 1 (HTLV-1) infection. It includes differing clinical forms classified as smoldering, chronic, lymphomatous, and acute ATLL. The Tax protein of HTLV-1 has been implicated as a viral oncoprotein which enhances virus replication and alters cellular gene expression, including activation of nuclear factor kappa B (NF kB), to result in lymphoid transformation. Chemotherapy for ATLL has had limited efficacy with median survivals of about 1 yr. Antiviral therapy employing zidovudine and interferon has shown promising results, as have antibody-based therapies to the interleukin 2 (IL2) receptor. Novel approaches employ a combination of chemo/antiretroviral therapy, hematopoietic stem cell transplantation, or inhibitors of NF kB activation.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15353320      PMCID： PMC2652732          DOI： 10.2741/1442

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  76 in total

1.  Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappa B activation.

Authors:  M E El-Sabban; R Nasr; G Dbaibo; O Hermine; N Abboushi; F Quignon; J C Ameisen; F Bex; H de Thé; A Bazarbachi
Journal:  Blood       Date:  2000-10-15       Impact factor: 22.113

Review 2.  T-cell receptors for cytokines: targets for immunotherapy of leukemia/lymphoma.

Authors:  T A Waldmann
Journal:  Ann Oncol       Date:  2000       Impact factor: 32.976

3.  Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation.

Authors:  A Utsunomiya; Y Miyazaki; Y Takatsuka; S Hanada; K Uozumi; S Yashiki; M Tara; F Kawano; Y Saburi; H Kikuchi; M Hara; H Sao; Y Morishima; Y Kodera; S Sonoda; M Tomonaga
Journal:  Bone Marrow Transplant       Date:  2001-01       Impact factor: 5.483

Review 4.  Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.

Authors:  M Yoshida
Journal:  Annu Rev Immunol       Date:  2001       Impact factor: 28.527

5.  Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site.

Authors:  J M Mariner; V Lantz; T A Waldmann; N Azimi
Journal:  J Immunol       Date:  2001-02-15       Impact factor: 5.422

6.  Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.

Authors:  C de La Fuente; F Santiago; S Y Chong; L Deng; T Mayhood; P Fu; D Stein; T Denny; F Coffman; N Azimi; R Mahieux; F Kashanchi
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

7.  p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells.

Authors:  S Takemoto; R Trovato; A Cereseto; C Nicot; T Kislyakova; L Casareto; T Waldmann; G Torelli; G Franchini
Journal:  Blood       Date:  2000-06-15       Impact factor: 22.113

8.  A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303.

Authors:  Y Yamada; M Tomonaga; H Fukuda; S Hanada; A Utsunomiya; M Tara; M Sano; S Ikeda; K Takatsuki; M Kozuru; K Araki; F Kawano; M Niimi; K Tobinai; T Hotta; M Shimoyama
Journal:  Br J Haematol       Date:  2001-05       Impact factor: 6.998

9.  Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies.

Authors:  R J Kreitman; W H Wilson; J D White; M Stetler-Stevenson; E S Jaffe; S Giardina; T A Waldmann; I Pastan
Journal:  J Clin Oncol       Date:  2000-04       Impact factor: 44.544

10.  Identification of genes associated with the progression of adult T cell leukemia (ATL).

Authors:  T Kohno; R Moriuchi; S Katamine; Y Yamada; M Tomonaga; T Matsuyama
Journal:  Jpn J Cancer Res       Date:  2000-11
View more
  18 in total

1.  HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition.

Authors:  Ling Gao; Hongju Deng; Haibo Zhao; Angela Hirbe; John Harding; Lee Ratner; Katherine Weilbaecher
Journal:  Blood       Date:  2005-08-23       Impact factor: 22.113

2.  High-yield production in E. coli and characterization of full-length functional p13II protein from human T-cell leukemia virus type 1.

Authors:  Elka R Georgieva; Peter P Borbat; Christina Fanouraki; Jack H Freed
Journal:  Protein Expr Purif       Date:  2020-04-30       Impact factor: 1.650

3.  Update on Neurological Manifestations of HTLV-1 Infection.

Authors:  Abelardo Q-C Araujo
Journal:  Curr Infect Dis Rep       Date:  2015-02       Impact factor: 3.725

Review 4.  Human T cell lymphotropic virus-associated leukemia/lymphoma.

Authors:  Lee Ratner
Journal:  Curr Opin Oncol       Date:  2005-09       Impact factor: 3.645

Review 5.  Pathogenesis and treatment of human T-cell leukemia virus infection.

Authors:  Lee Ratner
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

6.  Durable hematologic complete response and suppression of HTLV-1 viral load following alemtuzumab in zidovudine/IFN-{alpha}-refractory adult T-cell leukemia.

Authors:  Andrew Mone; Shannon Puhalla; Susan Whitman; Robert A Baiocchi; Julio Cruz; Tamara Vukosavljevic; Amy Banks; Charles F Eisenbeis; John C Byrd; Michael A Caligiuri; Pierluigi Porcu
Journal:  Blood       Date:  2005-08-02       Impact factor: 22.113

7.  Novel role for interleukin-2 receptor-Jak signaling in retrovirus transmission.

Authors:  J M Taylor; M Brown; M Nejmeddine; K J Kim; L Ratner; M Lairmore; C Nicot
Journal:  J Virol       Date:  2009-09-02       Impact factor: 5.103

8.  In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene.

Authors:  Lisa G Lanigan; Blake E Hildreth; Wessel P Dirksen; Jessica K Simmons; Chelsea K Martin; Jillian L Werbeck; Nandu K Thudi; Tracey L Papenfuss; Prosper N Boyaka; Ramiro E Toribio; Jerrold M Ward; Katherine N Weilbaecher; Thomas J Rosol
Journal:  Am J Pathol       Date:  2020-11-09       Impact factor: 4.307

9.  Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma.

Authors:  Daniel A Rauch; John C Harding; Lee Ratner; Samuel A Wickline; Hua Pan
Journal:  Nanomaterials (Basel)       Date:  2021-06-16       Impact factor: 5.076

10.  Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma.

Authors:  Lee Ratner; William Harrington; Xuan Feng; Christian Grant; Steve Jacobson; Ariela Noy; Joseph Sparano; Jeannette Lee; Richard Ambinder; Nancy Campbell; Michael Lairmore
Journal:  PLoS One       Date:  2009-02-10       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.