Literature DB >> 12542366

Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13.

Wen-Lin Li1, Yang-Hua Yi, Hou-Ming Wu, Qiang-Zhi Xu, Hai-Feng Tang, Da-Zheng Zhou, Hou-Wen Lin, Zhong-Hua Wang.   

Abstract

A new cyclic heptapeptide phakellistatin 13 (1) had been isolated from the sponge Phakellia fusca Thiele, collected at Yongxing Island of China. Its structure was elucidated as cyclo-(Pro1-Trp-Leu-Thr-Pro2-Gly-Phe) on the basis of MS, UV, IR, and high-field NMR (600 MHz) analysis. The compound was significantly cytotoxic against the human hepatoma BEL-7404 cell line with an ED(50) < 10(-2) microg/mL.

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Year:  2003        PMID： 12542366     DOI： 10.1021/np020223y

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  Bacterial and archaeal symbionts in the South China Sea sponge Phakellia fusca: community structure, relative abundance, and ammonia-oxidizing populations.

Authors:  Minqi Han; Fang Liu; Fengli Zhang; Zhiyong Li; Houwen Lin
Journal:  Mar Biotechnol (NY)       Date:  2012-02-05       Impact factor: 3.619

2.  Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.

Authors:  Rabab Mohammed; Jiangnan Peng; Michelle Kelly; Mark T Hamann
Journal:  J Nat Prod       Date:  2006-12       Impact factor: 4.050

Review 3.  Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.

Authors:  Vedanjali Gogineni; Mark T Hamann
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-08-24       Impact factor: 3.770

Review 4.  Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria.

Authors:  Kaarina Sivonen; Niina Leikoski; David P Fewer; Jouni Jokela
Journal:  Appl Microbiol Biotechnol       Date:  2010-02-27       Impact factor: 4.813

Review 5.  Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways.

Authors:  Srimanta Patra; Prakash Priyadarshi Praharaj; Debasna Pritimanjari Panigrahi; Biswajit Panda; Chandra Sekhar Bhol; Kewal Kumar Mahapatra; Soumya Ranjan Mishra; Bishnu Prasad Behera; Mrutyunjay Jena; Gautam Sethi; Shankargouda Patil; Samir Kumar Patra; Sujit Kumar Bhutia
Journal:  Mol Biol Rep       Date:  2020-08-14       Impact factor: 2.316

Review 6.  Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals.

Authors:  Guadalupe-Miroslava Suarez-Jimenez; Armando Burgos-Hernandez; Josafat-Marina Ezquerra-Brauer
Journal:  Mar Drugs       Date:  2012-04-26       Impact factor: 6.085

7.  Ketide Synthase (KS) Domain Prediction and Analysis of Iterative Type II PKS Gene in Marine Sponge-Associated Actinobacteria Producing Biosurfactants and Antimicrobial Agents.

Authors:  Joseph Selvin; Ganesan Sathiyanarayanan; Anuj N Lipton; Naif Abdullah Al-Dhabi; Mariadhas Valan Arasu; George S Kiran
Journal:  Front Microbiol       Date:  2016-02-12       Impact factor: 5.640

Review 8.  Phakellistatins: An Underwater Unsolved Puzzle.

Authors:  Alessandra Meli; Consiglia Tedesco; Giorgio Della Sala; Rosaria Schettini; Fernando Albericio; Francesco De Riccardis; Irene Izzo
Journal:  Mar Drugs       Date:  2017-03-18       Impact factor: 5.118

Review 9.  Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases.

Authors:  Ratih Pangestuti; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2017-03-09       Impact factor: 5.118

Review 10.  Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides.

Authors:  Kelly C L Mulder; Loiane A Lima; Vivian J Miranda; Simoni C Dias; Octávio L Franco
Journal:  Front Microbiol       Date:  2013-10-31       Impact factor: 5.640
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