| Literature DB >> 12537482 |
Leonardo Zayat1, Cecilia Calero, Pablo Alborés, Luis Baraldo, Roberto Etchenique.
Abstract
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.Entities:
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Year: 2003 PMID： 12537482 DOI： 10.1021/ja0278943
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419