Literature DB >> 12535868

Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro.

Pieter J Gaillard1, A Bert G de Boer, Douwe D Breimer.   

Abstract

Lipopolysaccharide-induced changes in blood-brain barrier (BBB) permeability were investigated with a pharmacological approach in vitro. Lipopolysaccharide induced a concentration- and time-dependent (non)reversible opening of the BBB, and brain astrocytes make brain capillary endothelial cells (BCEC) resistant to this BBB disruption. De novo protein synthesis was essential for the recovery, because cycloheximide prevented the recovery process. Dexamethasone pretreated BCEC were more resistant to lipopolysaccharide, while no protective response was induced by heat shock nor by inhibition of P-glycoprotein. BBB opening was tempered by free radical inhibitors (i.e., pretreatment with N-acetyl-cysteine or uric acid combined with deferroxamine mesylate). No effects of modulators of prostanoid-, leukotriene-, or platelet-activating factor pathways were observed. Therefore, lipopolysaccharide-induced BBB opening seems to be primarily mediated by excessive free radical production.

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Year:  2003        PMID： 12535868     DOI： 10.1016/s0026-2862(02)00009-2

Source DB:  PubMed          Journal:  Microvasc Res        ISSN： 0026-2862            Impact factor:   3.514


  21 in total

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10.  The role of dietary antioxidant insufficiency on the permeability of the blood-brain barrier.

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