Literature DB >> 16550324

Blood-brain barrier dysfunction and recovery.

A G de Boer1, P J Gaillard.   

Abstract

In this paper we discuss the importance of the blood-brain barrier (BBB) as an interface between blood and brain. Many (brain) diseases change the functionality and integrity of the BBB. Mostly this results in increased BBB permeability. Therefore we have studied de various signal transduction routes that are influenced by inflammatory stimuli. The radical scavenger N-acetylcysteine was able to protect the BBB against inflammatory stimuli. Similar results were found following application of glucocorticoids. In addition, it was observed that glucocorticoids and interferon-alpha,beta increased the tightness of the in vitro BBB and when given together a potentiating effect was seen.

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Year:  2006        PMID： 16550324     DOI： 10.1007/s00702-005-0375-4

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  32 in total

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5.  The expression of microfilament-associated cell-cell contacts in brain endothelial cells is modified by IFN-beta1a (Rebif).

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Review 10.  Immunology of multiple sclerosis.

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  22 in total

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Review 6.  Sepsis-Associated Encephalopathy: The Blood-Brain Barrier and the Sphingolipid Rheostat.

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7.  Assessment of P-glycoprotein activity in the Blood-Brain Barrier (BBB) using Near Infrared Fluorescence (NIRF) imaging techniques.

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Review 9.  Redox control of microglial function: molecular mechanisms and functional significance.

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Review 10.  Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules.

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