| Literature DB >> 12524170 |
Kenichi Mishima1, Takamitsu Tanaka, Fengling Pu, Nobuaki Egashira, Katsunori Iwasaki, Ryoji Hidaka, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Michihiro Fujiwara.
Abstract
Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.Entities:
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Year: 2003 PMID： 12524170 DOI： 10.1016/s0304-3940(02)01293-4
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046