| Literature DB >> 12522773 |
Malini D Coopamah1, M Bernadette Garvey, John Freedman, John W Semple.
Abstract
Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease. Copyright 2003, Elsevier Science (USA). All rights reserved.Entities:
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Year: 2003 PMID： 12522773 DOI： 10.1053/tmrv.2003.50004
Source DB: PubMed Journal: Transfus Med Rev ISSN： 0887-7963