| Literature DB >> 12521293 |
Jaekyung Shim1, Michael Karin.
Abstract
Regulated mRNA turnover is a highly important process in control of gene expression. The specific sequence elements in mRNA modulate the stability of different mRNAs, which varies considerably in response to extracellular stimuli. But the mechanistic basis for regulation of mRNA turnover remains nebulous. Recent works indicate that several signaling pathways have been implicated in regulating the decay of specific mRNA and certain ARE binding proteins mediate rapid degradation of the mRNAs. This review provides a current knowledge of diverse extracellular signals contributing to stabilization of short-lived mRNA.Mesh：
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Year: 2002 PMID： 12521293
Source DB: PubMed Journal: Mol Cells ISSN： 1016-8478 Impact factor: 5.034