| Literature DB >> 12521146 |
Abstract
Folate deficiency sensitizes mice to dopaminergic neurodegeneration and motor dysfunction caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Additional experiments indicate that this effect of folate deficiency may be mediated by homocysteine. These findings suggest that folate deficiency and hyperhomocysteinemia are risk factors for Parkinson's disease.Entities:
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Year: 2002 PMID： 12521146 DOI： 10.1301/002966402320964089
Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110