Literature DB >> 12510271

Accelerating water exchange for GdIII chelates by steric compression around the water binding site.

Robert Ruloff1, Eva Tóth, Rosario Scopelliti, Raphaël Tripier, Henri Handel, André E Merbach.   

Abstract

The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic GdIII complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA4- by a propylene bridge; in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H2O)]- is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.

Entities:  

Year:  2002        PMID： 12510271     DOI： 10.1039/b207713b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Toward the Design of MR Agents for Imaging β-Cell Function.

Authors:  Mark Woods; Shanrong Zhang; A Dean Sherry
Journal:  Curr Med Chem Immunol Endocr Metab Agents       Date:  2004-12

Review 2.  Alternatives to gadolinium-based metal chelates for magnetic resonance imaging.

Authors:  Subha Viswanathan; Zoltan Kovacs; Kayla N Green; S James Ratnakar; A Dean Sherry
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

3.  High relaxivity Gd(III)-DNA gold nanostars: investigation of shape effects on proton relaxation.

Authors:  Matthew W Rotz; Kayla S B Culver; Giacomo Parigi; Keith W MacRenaris; Claudio Luchinat; Teri W Odom; Thomas J Meade
Journal:  ACS Nano       Date:  2015-03-24       Impact factor: 15.881

Review 4.  Lanthanide probes for bioresponsive imaging.

Authors:  Marie C Heffern; Lauren M Matosziuk; Thomas J Meade
Journal:  Chem Rev       Date:  2013-12-13       Impact factor: 60.622

Review 5.  Basic MR relaxation mechanisms and contrast agent design.

Authors:  Luis M De León-Rodríguez; André F Martins; Marco C Pinho; Neil M Rofsky; A Dean Sherry
Journal:  J Magn Reson Imaging       Date:  2015-05-14       Impact factor: 4.813

6.  Substituent effects on Gd(III)-based MRI contrast agents: optimizing the stability and selectivity of the complex and the number of coordinated water molecules.

Authors:  Valérie C Pierre; Mauro Botta; Silvio Aime; Kenneth N Raymond
Journal:  Inorg Chem       Date:  2006-10-02       Impact factor: 5.165

7.  Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates.

Authors:  André F Martins; Alexandre C Oliveira; Jean-François Morfin; Douglas V Laurents; Éva Tóth; Carlos F G C Geraldes
Journal:  J Biol Inorg Chem       Date:  2015-11-27       Impact factor: 3.358

8.  Coupling fast water exchange to slow molecular tumbling in Gd3+ chelates: why faster is not always better.

Authors:  Stefano Avedano; Mauro Botta; Julian S Haigh; Dario L Longo; Mark Woods
Journal:  Inorg Chem       Date:  2013-07-10       Impact factor: 5.165

9.  Is macrocycle a synonym for kinetic inertness in Gd(III) Complexes? Effect of coordinating and noncoordinating substituents on inertness and relaxivity of Gd(III) chelates with DO3A-like ligands.

Authors:  Miloslav Polasek; Peter Caravan
Journal:  Inorg Chem       Date:  2013-03-21       Impact factor: 5.165

Review 10.  Strategies for optimizing water-exchange rates of lanthanide-based contrast agents for magnetic resonance imaging.

Authors:  Buddhima N Siriwardena-Mahanama; Matthew J Allen
Journal:  Molecules       Date:  2013-08-05       Impact factor: 4.411
  10 in total

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