Literature DB >> 12509760

A guide to drug discovery: Target selection in drug discovery.

Jonathan Knowles1, Gianni Gromo.   

Abstract

Target selection in drug discovery--defined here as the decision to focus on finding an agent with a particular biological action that is anticipated to have therapeutic utility--is influenced by a complex balance of scientific, medical and strategic considerations. In this article, we provide an introduction to the key issues in target selection and discuss the rationale for decision making.

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Year:  2003        PMID： 12509760     DOI： 10.1038/nrd986

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  36 in total

Review 1.  Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

Authors:  Bokyung Sung; Sahdeo Prasad; Vivek R Yadav; Bharat B Aggarwal
Journal:  Nutr Cancer       Date:  2011-12-09       Impact factor: 2.900

2.  Laboratory scale structural genomics.

Authors:  Brent W Segelke; Johana Schafer; Matthew A Coleman; Tim P Lekin; Dominique Toppani; Krzysztof J Skowronek; Katherine A Kantardjieff; Bernhard Rupp
Journal:  J Struct Funct Genomics       Date:  2004

Review 3.  Importance of microbial natural products and the need to revitalize their discovery.

Authors:  Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2013-08-30       Impact factor: 3.346

Review 4.  Recombinant organisms for production of industrial products.

Authors:  Jose-Luis Adrio; Arnold L Demain
Journal:  Bioeng Bugs       Date:  2009-11-02

Review 5.  Exploring the dark genome: implications for precision medicine.

Authors:  Tudor I Oprea
Journal:  Mamm Genome       Date:  2019-07-04       Impact factor: 2.957

Review 6.  Cardiovascular drug discovery: a perspective from a research-based pharmaceutical company.

Authors:  G Gromo; J Mann; J D Fitzgerald
Journal:  Cold Spring Harb Perspect Med       Date:  2014-06-02       Impact factor: 6.915

7.  PreDTIs: prediction of drug-target interactions based on multiple feature information using gradient boosting framework with data balancing and feature selection techniques.

Authors:  S M Hasan Mahmud; Wenyu Chen; Yongsheng Liu; Md Abdul Awal; Kawsar Ahmed; Md Habibur Rahman; Mohammad Ali Moni
Journal:  Brief Bioinform       Date:  2021-03-12       Impact factor: 11.622

Review 8.  Open access high throughput drug discovery in the public domain: a Mount Everest in the making.

Authors:  Anuradha Roy; Peter R McDonald; Sitta Sittampalam; Rathnam Chaguturu
Journal:  Curr Pharm Biotechnol       Date:  2010-11       Impact factor: 2.837

9.  Predicting drug-target interaction networks based on functional groups and biological features.

Authors:  Zhisong He; Jian Zhang; Xiao-He Shi; Le-Le Hu; Xiangyin Kong; Yu-Dong Cai; Kuo-Chen Chou
Journal:  PLoS One       Date:  2010-03-11       Impact factor: 3.240

Review 10.  Unexplored therapeutic opportunities in the human genome.

Authors:  Tudor I Oprea; Cristian G Bologa; Søren Brunak; Allen Campbell; Gregory N Gan; Anna Gaulton; Shawn M Gomez; Rajarshi Guha; Anne Hersey; Jayme Holmes; Ajit Jadhav; Lars Juhl Jensen; Gary L Johnson; Anneli Karlson; Andrew R Leach; Avi Ma'ayan; Anna Malovannaya; Subramani Mani; Stephen L Mathias; Michael T McManus; Terrence F Meehan; Christian von Mering; Daniel Muthas; Dac-Trung Nguyen; John P Overington; George Papadatos; Jun Qin; Christian Reich; Bryan L Roth; Stephan C Schürer; Anton Simeonov; Larry A Sklar; Noel Southall; Susumu Tomita; Ilinca Tudose; Oleg Ursu; Dušica Vidovic; Anna Waller; David Westergaard; Jeremy J Yang; Gergely Zahoránszky-Köhalmi
Journal:  Nat Rev Drug Discov       Date:  2018-03-23       Impact factor: 84.694
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