Literature DB >> 12509461

Chondromodulin I is a bone remodeling factor.

Yuko Nakamichi1, Chisa Shukunami, Takashi Yamada, Ken-ichi Aihara, Hirotaka Kawano, Takashi Sato, Yuriko Nishizaki, Yoko Yamamoto, Masayo Shindo, Kimihiro Yoshimura, Takashi Nakamura, Naoyuki Takahashi, Hiroshi Kawaguchi, Yuji Hiraki, Shigeaki Kato.   

Abstract

Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor.

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Year:  2003        PMID： 12509461      PMCID： PMC151528          DOI： 10.1128/MCB.23.2.636-644.2003

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  35 in total

1.  The production of transforming growth factor-beta by chick growth plate chondrocytes in short term monolayer culture.

Authors:  D E Gelb; R N Rosier; J E Puzas
Journal:  Endocrinology       Date:  1990-10       Impact factor: 4.736

2.  Increased bone formation in osteocalcin-deficient mice.

Authors:  P Ducy; C Desbois; B Boyce; G Pinero; B Story; C Dunstan; E Smith; J Bonadio; S Goldstein; C Gundberg; A Bradley; G Karsenty
Journal:  Nature       Date:  1996-08-01       Impact factor: 49.962

3.  Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease.

Authors:  D Uebelhart; E Gineyts; M C Chapuy; P D Delmas
Journal:  Bone Miner       Date:  1990-01

4.  Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.

Authors:  A M Parfitt; M K Drezner; F H Glorieux; J A Kanis; H Malluche; P J Meunier; S M Ott; R R Recker
Journal:  J Bone Miner Res       Date:  1987-12       Impact factor: 6.741

5.  A novel ES cell line, TT2, with high germline-differentiating potency.

Authors:  T Yagi; T Tokunaga; Y Furuta; S Nada; M Yoshida; T Tsukada; Y Saga; N Takeda; Y Ikawa; S Aizawa
Journal:  Anal Biochem       Date:  1993-10       Impact factor: 3.365

6.  Isolation and localization of basic fibroblast growth factor-immunoreactive substance in the epiphyseal growth plate.

Authors:  W O Twal; R Vasilatos-Younken; C V Gay; R M Leach
Journal:  J Bone Miner Res       Date:  1994-11       Impact factor: 6.741

7.  Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes.

Authors:  Y Hiraki; H Tanaka; H Inoue; J Kondo; A Kamizono; F Suzuki
Journal:  Biochem Biophys Res Commun       Date:  1991-03-29       Impact factor: 3.575

8.  Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

Authors:  A M Gonzalez; M Buscaglia; M Ong; A Baird
Journal:  J Cell Biol       Date:  1990-03       Impact factor: 10.539

9.  Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes.

Authors:  M A Moses; J Sudhalter; R Langer
Journal:  J Cell Biol       Date:  1992-10       Impact factor: 10.539

10.  MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.

Authors:  K Holmbeck; P Bianco; J Caterina; S Yamada; M Kromer; S A Kuznetsov; M Mankani; P G Robey; A R Poole; I Pidoux; J M Ward; H Birkedal-Hansen
Journal:  Cell       Date:  1999-10-01       Impact factor: 41.582
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  20 in total

1.  A functional role of the glycosylated N-terminal domain of chondromodulin-I.

Authors:  Jun Kondo; Hiroyuki Shibata; Shigenori Miura; Akira Yamakawa; Koji Sato; Yoshiki Higuchi; Chisa Shukunami; Yuji Hiraki
Journal:  J Bone Miner Metab       Date:  2010-05-27       Impact factor: 2.626

2.  Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays.

Authors:  Cynthia Wright; Sahar Sibani; David Trudgian; Roman Fischer; Benedikt Kessler; Joshua LaBaer; Paul Bowness
Journal:  Mol Cell Proteomics       Date:  2012-02       Impact factor: 5.911

Review 3.  Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse.

Authors:  Qing Xiong; Yan Jiao; Karen A Hasty; S Terry Canale; John M Stuart; Wesley G Beamer; Hong-Wen Deng; David Baylink; Weikuan Gu
Journal:  Genomics       Date:  2009-01-14       Impact factor: 5.736

4.  Genetic mapping of an autosomal recessive postaxial polydactyly type A to chromosome 13q13.3-q21.2 and screening of the candidate genes.

Authors:  Sulman Basit; Syed Kamran-ul-Hassan Naqvi; Muhammad Ansar; Wasim Ahmad
Journal:  Hum Genet       Date:  2011-08-30       Impact factor: 4.132

5.  Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice.

Authors:  Naoki Seito; Tadashi Yamashita; Yukinori Tsukuda; Yuichiro Matsui; Atsushi Urita; Tomohiro Onodera; Takeomi Mizutani; Hisashi Haga; Naoki Fujitani; Yasuro Shinohara; Akio Minami; Norimasa Iwasaki
Journal:  Arthritis Rheum       Date:  2012-08

6.  Tenomodulin is necessary for tenocyte proliferation and tendon maturation.

Authors:  Denitsa Docheva; Ernst B Hunziker; Reinhard Fässler; Oliver Brandau
Journal:  Mol Cell Biol       Date:  2005-01       Impact factor: 4.272

7.  In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones.

Authors:  Olivier Duverger; Juliane Isaac; Angela Zah; Joonsung Hwang; Ariane Berdal; Jane B Lian; Maria I Morasso
Journal:  J Cell Physiol       Date:  2013-03       Impact factor: 6.384

8.  MEMO1 drives cranial endochondral ossification and palatogenesis.

Authors:  Eric Van Otterloo; Weiguo Feng; Kenneth L Jones; Nancy E Hynes; David E Clouthier; Lee Niswander; Trevor Williams
Journal:  Dev Biol       Date:  2015-12-31       Impact factor: 3.582

9.  Suppressive function of androgen receptor in bone resorption.

Authors:  Hirotaka Kawano; Takashi Sato; Takashi Yamada; Takahiro Matsumoto; Keisuke Sekine; Tomoyuki Watanabe; Takashi Nakamura; Toru Fukuda; Kimihiro Yoshimura; Tatsuya Yoshizawa; Ken-Ichi Aihara; Yoko Yamamoto; Yuko Nakamichi; Daniel Metzger; Pierre Chambon; Kozo Nakamura; Hiroshi Kawaguchi; Shigeaki Kato
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-18       Impact factor: 11.205

10.  Chondromodulin-1 directly suppresses growth of human cancer cells.

Authors:  Hisashi Mera; Hiroyuki Kawashima; Tatsuya Yoshizawa; Osamu Ishibashi; Md Moksed Ali; Tadashi Hayami; Hiroshi Kitahara; Hiroshi Yamagiwa; Naoki Kondo; Akira Ogose; Naoto Endo; Hiroyuki Kawashima
Journal:  BMC Cancer       Date:  2009-05-31       Impact factor: 4.430
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