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Literature DB >> 1250892

Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue.

Abstract

No differences in appearance or in cell size distribution were observed between cultured fibroblasts derived from normal skin, mature scars, or keloids. Artifactual differences in cell size distributions between strains can result when populations are compared at different cell densities. Keloid derived fibroblasts remain euploid in culture, and they have the same growth rate and same degree of density-dependent growth inhibition as cultured normal human fibroblasts.

Entities: Species

Mesh：

Year: 1976 PMID： 1250892 DOI： 10.1097/00006534-197602000-00014

Source DB: PubMed Journal: Plast Reconstr Surg ISSN： 0032-1052 Impact factor: 4.730

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Cited

11 in total

1. Genetic control of variation in human gingival fibroblast proliferation rate.

Authors: G H Cockey; J A Boughman; E L Harris; T M Hassell
Journal: In Vitro Cell Dev Biol Date: 1989-03

2. Studies on the immunologic aspects of keloids and hypertrophic scars.

Authors: A M Janssen de Limpens; R H Cormane
Journal: Arch Dermatol Res Date: 1982 Impact factor: 3.017

3. Keloids and hypertrophic scars--immunological aspects.

Authors: A M Janssen de Limpens; R H Cormane
Journal: Aesthetic Plast Surg Date: 1982 Impact factor: 2.326

4. Fibroblast heterogeneity in glucocorticoid regulation of collagen metabolism: genetic or epigenetic?

Authors: J D Russell; S B Russell; K M Trupin
Journal: In Vitro Date: 1982-06

Review 5. The biology and control of surface overhealing.

Authors: I K Cohen; B J McCoy
Journal: World J Surg Date: 1980-05 Impact factor: 3.352

6. Effects of density and cellular aging on collagen synthesis and growth kinetics in keloid and normal skin fibroblasts.

Authors: B J McCoy; J Galdun; I K Cohen
Journal: In Vitro Date: 1982-01

Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue.

1. Genetic control of variation in human gingival fibroblast proliferation rate.

2. Studies on the immunologic aspects of keloids and hypertrophic scars.

3. Keloids and hypertrophic scars--immunological aspects.

4. Fibroblast heterogeneity in glucocorticoid regulation of collagen metabolism: genetic or epigenetic?

Review 5. The biology and control of surface overhealing.

6. Effects of density and cellular aging on collagen synthesis and growth kinetics in keloid and normal skin fibroblasts.

7. Identification and characterization of cartilage oligomeric matrix protein as a novel pathogenic factor in keloids.

8. MRP1 knockdown down-regulates the deposition of collagen and leads to a reduced hypertrophic scar fibrosis.

9. Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth.

10. Altered cytokine production in black patients with keloids.