Literature DB >> 12499223

Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.

Brent W Gunderson1, Khalid H Ibrahim, Charles A Peloquin, Laurie B Hovde, John C Rotschafer.   

Abstract

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log(10) killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.

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Year:  2003        PMID： 12499223      PMCID： PMC148952          DOI： 10.1128/AAC.47.1.398-399.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

Authors:  J Li; J Turnidge; R Milne; R L Nation; K Coulthard
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

2.  The antibacterial activity of vancomycin towards Staphylococcus aureus under aerobic and anaerobic conditions.

Authors:  M T E Suller; D Lloyd
Journal:  J Appl Microbiol       Date:  2002       Impact factor: 3.772

Review 3.  Influence of protein binding of antibiotics on serum pharmacokinetics and extravascular penetration: clinically useful concepts.

Authors:  L R Peterson; D N Gerding
Journal:  Rev Infect Dis       Date:  1980 May-Jun

4.  Linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft tissue bite infections in humans.

Authors:  E J Goldstein; D M Citron; C V Merriam
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

5.  Evaluation of activity of temafloxacin against Bacteroides fragilis by an in vitro pharmacodynamic system.

Authors:  R A Zabinski; K Vance-Bryan; A J Krinke; K J Walker; J A Moody; J C Rotschafer
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191
  5 in total
  6 in total

1.  Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model.

Authors:  Lauren M Boak; Jian Li; Craig R Rayner; Roger L Nation
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

2.  Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model.

Authors:  Kerry L LaPlante; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

3.  Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.

Authors:  Brian T Tsuji; Tanya Brown; Ridhi Parasrampuria; Daniel A Brazeau; Alan Forrest; Pamela A Kelchlin; Patricia N Holden; Charles A Peloquin; Debra Hanna; Jurgen B Bulitta
Journal:  Antimicrob Agents Chemother       Date:  2012-04-23       Impact factor: 5.191

4.  Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme.

Authors:  Craig R Rayner; Alan Forrest; Alison K Meagher; Mary C Birmingham; Jerome J Schentag
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

5.  Concentrations in plasma, urinary excretion, and bactericidal activity of linezolid (600 milligrams) versus those of ciprofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.

Authors:  Florian M E Wagenlehner; Stephan Wydra; Hajime Onda; Martina Kinzig-Schippers; Fritz Sörgel; Kurt G Naber
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

6.  Development and Validation of an HPLC-UV Method for Quantitation of Linezolid: Application to Resistance Study Using in vitro PK/PD Model.

Authors:  Guang Yang; Yisong Yan; Jun Mao; Huiping Liu; Mingtao Chen; Na Zhang; Yaowen Li; Jiangjun Gu; Xiaohui Huang
Journal:  Infect Drug Resist       Date:  2021-12-01       Impact factor: 4.003
  6 in total

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