Literature DB >> 12499218

Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library.

Michael S Scherman1, Katharine A Winans, Richard J Stern, Victoria Jones, Carolyn R Bertozzi, Michael R McNeil.   

Abstract

A microtiter plate assay for UDP-galactopyranose mutase, an essential cell wall biosynthetic enzyme of Mycobacterium tuberculosis, was developed. The assay is based on the release of tritiated formaldehyde from UDP-galactofuranose but not UDP-galactopyranose by periodate and was used to identify a uridine-based enzyme inhibitor from a chemical library.

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Year:  2003        PMID： 12499218      PMCID： PMC148999          DOI： 10.1128/AAC.47.1.378-382.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Escherichia coli K12 regains its O antigen.

Authors:  D Liu; P R Reeves
Journal:  Microbiology       Date:  1994-01       Impact factor: 2.777

2.  An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation.

Authors:  Katharine A Winans; Carolyn R Bertozzi
Journal:  Chem Biol       Date:  2002-01

3.  Enzymatic synthesis of UDP-galactofuranose and an assay for UDP-galactopyranose mutase based on high-performance liquid chromatography.

Authors:  R Lee; D Monsey; A Weston; K Duncan; C Rithner; M McNeil
Journal:  Anal Biochem       Date:  1996-11-01       Impact factor: 3.365

4.  Initiating a crystallographic study of UDP-galactopyranose mutase from Escherichia coli.

Authors:  S A McMahon; G A Leonard; L V Buchanan; M F Giraud; J H Naismith
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-02

5.  Cell wall core galactofuran synthesis is essential for growth of mycobacteria.

Authors:  F Pan; M Jackson; Y Ma; M McNeil
Journal:  J Bacteriol       Date:  2001-07       Impact factor: 3.490

6.  UDP-galactopyranose mutase has a novel structure and mechanism.

Authors:  D A Sanders; A G Staines; S A McMahon; M R McNeil; C Whitfield; J H Naismith
Journal:  Nat Struct Biol       Date:  2001-10

7.  Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues.

Authors:  A Weston; R J Stern; R E Lee; P M Nassau; D Monsey; S L Martin; M S Scherman; G S Besra; K Duncan; M R McNeil
Journal:  Tuber Lung Dis       Date:  1997

8.  Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase.

Authors:  P M Nassau; S L Martin; R E Brown; A Weston; D Monsey; M R McNeil; K Duncan
Journal:  J Bacteriol       Date:  1996-02       Impact factor: 3.490

9.  Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster.

Authors:  G Stevenson; B Neal; D Liu; M Hobbs; N H Packer; M Batley; J W Redmond; L Lindquist; P Reeves
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490
  9 in total
  22 in total

Review 1.  Targeting the formation of the cell wall core of M. tuberculosis.

Authors:  Clifton E Barry; Dean C Crick; Michael R McNeil
Journal:  Infect Disord Drug Targets       Date:  2007-06

2.  High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.

Authors:  Subramaniam Ananthan; Ellen R Faaleolea; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Barbara E Laughon; Joseph A Maddry; Alka Mehta; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Nice Shindo; Dustin N Showe; Melinda I Sosa; William J Suling; E Lucile White
Journal:  Tuberculosis (Edinb)       Date:  2009-09-15       Impact factor: 3.131

Review 3.  Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules.

Authors:  Kazunobu Toshima; Daisuke Takahashi
Journal:  Glycoconj J       Date:  2015-04-28       Impact factor: 2.916

4.  Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: implication for an oxocarbenium ion intermediate in the catalytic mechanism.

Authors:  Kenji Itoh; Zhishu Huang; Hung-wen Liu
Journal:  Org Lett       Date:  2007-02-01       Impact factor: 6.005

5.  Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP-Galactopyranose Mutase Probes.

Authors:  Valerie J Winton; Claudia Aldrich; Laura L Kiessling
Journal:  ACS Infect Dis       Date:  2016-06-29       Impact factor: 5.084

6.  Investigation of binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose mutase by STD-NMR spectroscopy, molecular dynamics, and CORCEMA-ST calculations.

Authors:  Yue Yuan; Dustin W Bleile; Xin Wen; David A R Sanders; Kenji Itoh; Hung-wen Liu; B Mario Pinto
Journal:  J Am Chem Soc       Date:  2008-02-16       Impact factor: 15.419

7.  Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.

Authors:  Virginia A Kincaid; Nir London; Kittikhun Wangkanont; Darryl A Wesener; Sarah A Marcus; Annie Héroux; Lyudmila Nedyalkova; Adel M Talaat; Katrina T Forest; Brian K Shoichet; Laura L Kiessling
Journal:  ACS Chem Biol       Date:  2015-08-17       Impact factor: 5.100

8.  Ligand binding and substrate discrimination by UDP-galactopyranose mutase.

Authors:  Todd D Gruber; M Jack Borrok; William M Westler; Katrina T Forest; Laura L Kiessling
Journal:  J Mol Biol       Date:  2009-06-03       Impact factor: 5.469

9.  Substrate-dependent dynamics of UDP-galactopyranose mutase: Implications for drug design.

Authors:  Leonardo Boechi; Cesar Augusto F de Oliveira; Isabel Da Fonseca; Karina Kizjakina; Pablo Sobrado; John J Tanner; J Andrew McCammon
Journal:  Protein Sci       Date:  2013-09-17       Impact factor: 6.725

10.  Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite.

Authors:  Emily C Dykhuizen; Laura L Kiessling
Journal:  Org Lett       Date:  2009-01-01       Impact factor: 6.005
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