Literature DB >> 12499214

Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages.

Tetsuji Nakano1, Kazufumi Hiramatsu, Kenji Kishi, Norio Hirata, Jun-Ichi Kadota, Masaru Nasu.   

Abstract

We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.

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Year:  2003        PMID： 12499214      PMCID： PMC148975          DOI： 10.1128/AAC.47.1.363-367.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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3.  Protection from doxorubicin-induced nephrotoxicity by clindamycin: novel antioxidant, anti-inflammatory and anti-apoptotic roles.

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Review 6.  Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.

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Review 7.  Anti-inflammatory and Immunomodulatory Effects of Antibiotics and Their Use in Dermatology.

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Review 8.  Multitarget Approaches against Multiresistant Superbugs.

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